Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections-needs, advances, and future prospects

Alimuddin Zumla, Jaffar A. Al-Tawfiq, Virve I. Enne, Mike Kidd, Christian Drosten, Judy Breuer, Marcel A. Muller, David Hui, Markus Maeurer, Matthew Bates, Peter Mwaba, Rafaat Al-Hakeem, Gregory Gray, Philippe Gautret, Abdullah A. Al-Rabeeah, Ziad A. Memish, Vanya Gant

Research output: Contribution to journalReview articlepeer-review

113 Scopus citations

Abstract

Respiratory tract infections rank second as causes of adult and paediatric morbidity and mortality worldwide. Respiratory tract infections are caused by many different bacteria (including mycobacteria) and viruses, and rapid detection of pathogens in individual cases is crucial in achieving the best clinical management, public health surveillance, and control outcomes. Further challenges in improving management outcomes for respiratory tract infections exist: rapid identification of drug resistant pathogens; more widespread surveillance of infections, locally and internationally; and global responses to infections with pandemic potential. Developments in genome amplification have led to the discovery of several new respiratory pathogens, and sensitive PCR methods for the diagnostic work-up of these are available. Advances in technology have allowed for development of single and multiplexed PCR techniques that provide rapid detection of respiratory viruses in clinical specimens. Microarray-based multiplexing and nucleic-acid-based deep-sequencing methods allow simultaneous detection of pathogen nucleic acid and multiple antibiotic resistance, providing further hope in revolutionising rapid point of care respiratory tract infection diagnostics.

Original languageEnglish (US)
Pages (from-to)1123-1135
Number of pages13
JournalThe Lancet Infectious Diseases
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases

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