Rate process model for arterial tissue thermal damage

Implications on vessel photocoagulation

R. Agah, J. A. Pearce, A. J. Welch, Massoud Motamedi

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

A numerical model for thermal damage to human arterial tissue is presented, based on protein denaturation kinetics. The model involves determination of coefficients of rate processes A and ΔE, which are tissue type-dependent (arterial tissue in this study), and definition of threshold damage. A feedback-controlled constant surface temperature device was used to induce 80 coagulative lesions of arterial human tissue ranging in temperature from 66°C to 76°C and in duration from 15 to 1,500 seconds. The measured coefficients were determined to be A = 5.6 x 1063 s-1 and ΔE = 430 KJ mole-1. These numerical values closely approximate the coefficients of the rate process for denaturation of collagen molecules. These and other histological observations strongly suggest collagen to be the primary coagulating component of arterial tissue at the onset of thermal coagulative damage. The ability of this model to predict onset of tissue coagulation during laser coagulation was studied using 10 postmortem human arterial samples exposed to argon laser irradiation.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalLasers in Surgery and Medicine
Volume15
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Light Coagulation
Hot Temperature
Collagen
Laser Coagulation
Protein Denaturation
Temperature
Argon
Lasers
Equipment and Supplies

Keywords

  • arterial tissue
  • collagen fibrils
  • laser-tissue modeling
  • thermal damage

ASJC Scopus subject areas

  • Surgery

Cite this

Rate process model for arterial tissue thermal damage : Implications on vessel photocoagulation. / Agah, R.; Pearce, J. A.; Welch, A. J.; Motamedi, Massoud.

In: Lasers in Surgery and Medicine, Vol. 15, No. 2, 1994, p. 176-184.

Research output: Contribution to journalArticle

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