Abstract
Bartonella species were isolated from the blood of 63 of 325 Rattus norvegicus and 11 of 92 Rattus rattus from 13 sites in the United States and Portugal. Infection in both Rattus species ranged from 0% (e.g., 0/87) to ~60% (e.g., 35/62). A 337-bp fragment of the citrate synthase (gltA) gene amplified by polymerase chain reaction was sequenced from all 74 isolates. Isolates from R. norvegicus were most similar to Bartonella elizabethae, isolated previously from a patient with endocardil is (93%-100% sequence similarity), followed by Bartonella grahamii and other Bartonella species isolated from Old World rodents (Clethrionomys species, Mus musculus, and Rattus species). These data suggest that Rattus species are a reservoir host for pathogenic Bartonella species and are consistent with a hypothesized Old World origin for Bartonella species recovered from Rattus species introduced into the Americas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 220-224 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 180 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Rats of the genus Rattus are reservoir hosts for pathogenic Bartonella species : An old world origin for a new world disease? / Ellis, B. A.; Regnery, R. L.; Beati, L.; Bacellar, F.; Rood, M.; Glass, G. G.; Marston, E.; Ksiazek, Thomas; Jones, D.; Childs, J. E.
In: Journal of Infectious Diseases, Vol. 180, No. 1, 1999, p. 220-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rats of the genus Rattus are reservoir hosts for pathogenic Bartonella species
T2 - An old world origin for a new world disease?
AU - Ellis, B. A.
AU - Regnery, R. L.
AU - Beati, L.
AU - Bacellar, F.
AU - Rood, M.
AU - Glass, G. G.
AU - Marston, E.
AU - Ksiazek, Thomas
AU - Jones, D.
AU - Childs, J. E.
PY - 1999
Y1 - 1999
N2 - Bartonella species were isolated from the blood of 63 of 325 Rattus norvegicus and 11 of 92 Rattus rattus from 13 sites in the United States and Portugal. Infection in both Rattus species ranged from 0% (e.g., 0/87) to ~60% (e.g., 35/62). A 337-bp fragment of the citrate synthase (gltA) gene amplified by polymerase chain reaction was sequenced from all 74 isolates. Isolates from R. norvegicus were most similar to Bartonella elizabethae, isolated previously from a patient with endocardil is (93%-100% sequence similarity), followed by Bartonella grahamii and other Bartonella species isolated from Old World rodents (Clethrionomys species, Mus musculus, and Rattus species). These data suggest that Rattus species are a reservoir host for pathogenic Bartonella species and are consistent with a hypothesized Old World origin for Bartonella species recovered from Rattus species introduced into the Americas.
AB - Bartonella species were isolated from the blood of 63 of 325 Rattus norvegicus and 11 of 92 Rattus rattus from 13 sites in the United States and Portugal. Infection in both Rattus species ranged from 0% (e.g., 0/87) to ~60% (e.g., 35/62). A 337-bp fragment of the citrate synthase (gltA) gene amplified by polymerase chain reaction was sequenced from all 74 isolates. Isolates from R. norvegicus were most similar to Bartonella elizabethae, isolated previously from a patient with endocardil is (93%-100% sequence similarity), followed by Bartonella grahamii and other Bartonella species isolated from Old World rodents (Clethrionomys species, Mus musculus, and Rattus species). These data suggest that Rattus species are a reservoir host for pathogenic Bartonella species and are consistent with a hypothesized Old World origin for Bartonella species recovered from Rattus species introduced into the Americas.
UR - http://www.scopus.com/inward/record.url?scp=0033016335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033016335&partnerID=8YFLogxK
U2 - 10.1086/314824
DO - 10.1086/314824
M3 - Article
C2 - 10353885
AN - SCOPUS:0033016335
VL - 180
SP - 220
EP - 224
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -