Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C Signaling

Sunil K. Verma, Vaibhav Deshmukh, Patrick Liu, Curtis A. Nutter, Rosario Espejo, Ming Lung Hung, Guey Shin Wang, Gene W. Yeo, Neslihan Martinez

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Chronic PKC activation is the leading pathogenic component of diabetes in the heart. Results: PKCα/β promotes fetal splicing patterns in adult diabetic hearts via phosphorylation of the RNA-binding proteins CELF1 and Rbfox2. Conclusion: PKCα/β contributes to diabetes pathogenesis by manipulating developmentally regulated alternative splicing. Significance: Identifying downstream effectors of PKC can provide novel therapeutics for cardiac pathogenesis of diabetes.

Original languageEnglish (US)
Pages (from-to)35372-35386
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
StatePublished - Dec 6 2013

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Medical problems
Protein Kinase C
RNA-Binding Proteins
Alternative Splicing
Phosphorylation
Chemical activation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C Signaling. / Verma, Sunil K.; Deshmukh, Vaibhav; Liu, Patrick; Nutter, Curtis A.; Espejo, Rosario; Hung, Ming Lung; Wang, Guey Shin; Yeo, Gene W.; Martinez, Neslihan.

In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35372-35386.

Research output: Contribution to journalArticle

Verma, SK, Deshmukh, V, Liu, P, Nutter, CA, Espejo, R, Hung, ML, Wang, GS, Yeo, GW & Martinez, N 2013, 'Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C Signaling', Journal of Biological Chemistry, vol. 288, no. 49, pp. 35372-35386. https://doi.org/10.1074/jbc.M113.507426
Verma, Sunil K. ; Deshmukh, Vaibhav ; Liu, Patrick ; Nutter, Curtis A. ; Espejo, Rosario ; Hung, Ming Lung ; Wang, Guey Shin ; Yeo, Gene W. ; Martinez, Neslihan. / Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C Signaling. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 49. pp. 35372-35386.
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