Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors

Rinat Esenaliev, Y. Y. Petrov, I. Cicenaite, O. V. Chumakova, I. Y. Petrova, I. Patrikeev, A. Liopo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We proposed and have been developing real-time, noninvasive monitoring of blood oxygenation, total hemoglobin concentration, and thermotherapy including hyperthermia, coagulation, and cryotherapy. In this paper we propose to use the optoacoustic technique for monitoring of nanoparticle-mediated photothermal therapy (NPT) of tumors. NPT is based on heating exogenous strongly-absorbing nanoparticles selectively delivered in tumors. Real-time monitoring of NPT is necessary for precise tumor therapy with minimal damage to normal tissues. In this study we injected PEGylated and non-PEGylated carbon nanoparticles in nude mice bearing human tumors (5-15 mm) and irradiated the tumors for 10 minutes with nanosecond Nd:YAG laser pulses which produced both thermal damage to the tumors and optoacoustic signals for monitoring NPT in real time. Irradiation of tumors was performed during or after (3 or 24 hours) nanoparticle injection. Amplitude and temporal parameters of optoacoustic signals (measured with a custom-made wide-band optoacoustic probe) correlated well with nanoparticle injection, temperature rise in tumors, and tumor coagulation. Substantial thermal damage in large areas of the tumors was produced when optimal irradiation parameters were used. Monte Carlo modeling of light distribution in tumors and optoacoustic theory were applied to study kinetics of nanoparticle concentration in the tumors. Our results demonstrated that the optoacoustic technique can be used for real-time monitoring of NTP and provide precise tumor therapy with minimal damage to normal tissues.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6437
DOIs
StatePublished - 2007
EventPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
CountryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Fingerprint

Photoacoustic effect
Tumors
Nanoparticles
Monitoring
Coagulation
Cryotherapy
Bearings (structural)
Irradiation
Tissue
Oxygenation
Hemoglobin
Laser pulses
Blood

Keywords

  • Nanoparticle
  • Optoacoustics
  • Thermotherapy
  • Tumor

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Esenaliev, R., Petrov, Y. Y., Cicenaite, I., Chumakova, O. V., Petrova, I. Y., Patrikeev, I., & Liopo, A. (2007). Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6437). [64370Q] https://doi.org/10.1117/12.714302

Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors. / Esenaliev, Rinat; Petrov, Y. Y.; Cicenaite, I.; Chumakova, O. V.; Petrova, I. Y.; Patrikeev, I.; Liopo, A.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007. 64370Q.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Esenaliev, R, Petrov, YY, Cicenaite, I, Chumakova, OV, Petrova, IY, Patrikeev, I & Liopo, A 2007, Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6437, 64370Q, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.714302
Esenaliev R, Petrov YY, Cicenaite I, Chumakova OV, Petrova IY, Patrikeev I et al. Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437. 2007. 64370Q https://doi.org/10.1117/12.714302
Esenaliev, Rinat ; Petrov, Y. Y. ; Cicenaite, I. ; Chumakova, O. V. ; Petrova, I. Y. ; Patrikeev, I. ; Liopo, A. / Real-time, noninvasive optoacoustic monitoring of nanoparticle-mediated photothermal therapy of tumors. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007.
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