Real-time optoacoustic monitoring during thermotherapy

Rinat Esenaliev, Irina Larina, Kirill Larin, Massoud Motamedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Citations (Scopus)

Abstract

Optoacoustic monitoring of tissue optical properties and speed of sound in real time can provide fast and accurate feedback information during thermotherapy performed with various heating or cooling agents. Amplitude and temporal characteristics of optoacoustic pressure waves are dependent on tissue properties. Detection and measurement of the optoacoustic waves may be used to monitor the extent of tissue hyperthermia, coagulation, or freezing with high resolution and contrast. We studied real-time optoacoustic monitoring of thermal coagulation induced by conductive heating and laser radiation and cryoablation with liquid nitrogen. Q-switched Nd:YAG laser pulses were used as probing radiation to induce optoacoustic waves in tissues. Dramatic changes in optoacoustic signal parameters were detected during tissue freezing and coagulation due to sharp changes in tissue properties. The dimensions of thermally-induced lesions were measured in real time with the optoacoustic technique. Our studies demonstrated that the laser optoacoustic technique is capable of real-time monitoring of tissue coagulation and freezing front with submillimeter spatial resolution. This may allow accurate thermal ablation or cryotherapy of malignant and benign lesions with minimal damage to normal tissues.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages302-310
Number of pages9
Volume3916
StatePublished - 2000
EventBiomedical Optoacoustics - San Jose, CA, USA
Duration: Jan 25 2000Jan 26 2000

Other

OtherBiomedical Optoacoustics
CitySan Jose, CA, USA
Period1/25/001/26/00

Fingerprint

Photoacoustic effect
Tissue
Monitoring
coagulation
Coagulation
Freezing
freezing
lesions
Cryotherapy
radiant heating
Heating
hyperthermia
Acoustic wave velocity
Q switched lasers
Liquid nitrogen
Laser radiation
Ablation
elastic waves
liquid nitrogen
ablation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Esenaliev, R., Larina, I., Larin, K., & Motamedi, M. (2000). Real-time optoacoustic monitoring during thermotherapy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3916, pp. 302-310). Society of Photo-Optical Instrumentation Engineers.

Real-time optoacoustic monitoring during thermotherapy. / Esenaliev, Rinat; Larina, Irina; Larin, Kirill; Motamedi, Massoud.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3916 Society of Photo-Optical Instrumentation Engineers, 2000. p. 302-310.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Esenaliev, R, Larina, I, Larin, K & Motamedi, M 2000, Real-time optoacoustic monitoring during thermotherapy. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3916, Society of Photo-Optical Instrumentation Engineers, pp. 302-310, Biomedical Optoacoustics, San Jose, CA, USA, 1/25/00.
Esenaliev R, Larina I, Larin K, Motamedi M. Real-time optoacoustic monitoring during thermotherapy. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3916. Society of Photo-Optical Instrumentation Engineers. 2000. p. 302-310
Esenaliev, Rinat ; Larina, Irina ; Larin, Kirill ; Motamedi, Massoud. / Real-time optoacoustic monitoring during thermotherapy. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3916 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 302-310
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