Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance

Pablo A. Valdes, Joseph Angelo, Sylvain Gioux

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Fluorescence imaging has shown promise as an adjunct to improve the extent of resection in neurosurgery and oncologic surgery. Nevertheless, current fluorescence imaging techniques do not account for the heterogeneous attenuation effects of tissue optical properties. In this work, we present a novel imaging system that performs real time quantitative fluorescence imaging using Single Snapshot Optical Properties (SSOP) imaging. We developed the technique and performed initial phantom studies to validate the quantitative capabilities of the system for intraoperative feasibility. Overall, this work introduces a novel real-time quantitative fluorescence imaging method capable of being used intraoperatively for neurosurgical guidance.

Original languageEnglish (US)
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
EditorsHenry Hirschberg, Steen J. Madsen, Qingming Luo, Samarendra K. Mohanty, Nitish V. Thakor, E. Duco Jansen
PublisherSPIE
ISBN (Electronic)9781628413953
DOIs
StatePublished - 2015
Externally publishedYes
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II - San Francisco, United States
Duration: Feb 7 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9305
ISSN (Print)1605-7422

Conference

ConferenceOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Country/TerritoryUnited States
CitySan Francisco
Period2/7/152/10/15

Keywords

  • Fluorescence guided surgery
  • intrinsic fluorescence
  • neurosurgery
  • quantitative fluorescence
  • single snapshot optical properties

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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