Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Niranjan G. Kotla, Srinivasa Reddy Bonam, Swetha Rasala, Jitendra Wankar, Raghvendra A. Bohara, Jagadeesh Bayry, Yury Rochev, Abhay Pandit

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-surface-associated biopolymer and is the key component of tissue extracellular matrix (ECM). Along with remarkable physicochemical properties, HA also has multifaceted biological effects that include but not limited to ECM organization, immunomodulation, and various cellular processes. Environmental cues such as tissue injury, infection or cancer change downstream signaling functionalities of HA. Unlike native HA, the fragments of HA have diversified effects on inflammation, cancer, fibrosis, angiogenesis and autoimmune response. In this review, we aim to discuss HA as a therapeutic delivery system development process, source, biophysical-chemical properties, and associated biological pathways (especially via cell surface receptors) of native and fragmented HA. We also tried to address an overview of the potential role of HA (native HA vs fragments) in the modulation of inflammation, immune response and various cancer targeting delivery applications. This review will also highlight the HA based therapeutic systems, medical devices and future perspectives of various biomedical applications were discussed in detail.

Original languageEnglish (US)
Pages (from-to)598-620
Number of pages23
JournalJournal of Controlled Release
Volume336
DOIs
StatePublished - Aug 10 2021
Externally publishedYes

Keywords

  • Cancer
  • Drug delivery
  • Hyaluronic acid
  • Immunity
  • Inflammation
  • Low and high molecular weight HA

ASJC Scopus subject areas

  • Pharmaceutical Science

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