Recent advances in adherence and invasion of pathogenic Escherichia coli

Anjana Kalita, Jia Hu, Alfredo Torres

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Colonization of the host epithelia by pathogenic Escherichia coli is influenced by the ability of the bacteria to interact with host surfaces. Because the initial step of an E. coli infection is to adhere, invade, and persist within host cells, some strategies used by intestinal and extraintestinal E. coli to infect host cell are presented. RECENT FINDINGS: This review highlights recent progress understanding how extraintestinal pathogenic E. coli strains express specific adhesins or invasins that allow colonization of the urinary tract or the meninges, while intestinal E. coli strains are able to colonize different regions of the intestinal tract using other specialized adhesins or invasins. Finally, evaluation of different diets and environmental conditions regulating the colonization of these pathogens is discussed. SUMMARY: Discovery of new interactions between pathogenic E. coli and the host epithelial cells unravels the need for more mechanistic studies that can provide new clues regarding how to combat these infections.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume27
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Escherichia coli
Escherichia coli Infections
Meninges
Urinary Tract
Epithelium
Epithelial Cells
Diet
Bacteria
Infection
Extraintestinal Pathogenic Escherichia coli

Keywords

  • adherent invasive Escherichia coli
  • enteroaggregative
  • enterohemorrhagic Escherichia coli
  • enteropathogenic
  • enterotoxigenic
  • uropathogenic

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Recent advances in adherence and invasion of pathogenic Escherichia coli. / Kalita, Anjana; Hu, Jia; Torres, Alfredo.

In: Current Opinion in Infectious Diseases, Vol. 27, No. 5, 2014, p. 459-464.

Research output: Contribution to journalArticle

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