TY - JOUR
T1 - Recent advances in flavivirus antiviral drug discovery and vaccine development.
AU - Ray, Debashish
AU - Shi, Pei Yong
PY - 2006/1
Y1 - 2006/1
N2 - Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.
AB - Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.
UR - http://www.scopus.com/inward/record.url?scp=34748891739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34748891739&partnerID=8YFLogxK
U2 - 10.2174/157489106775244055
DO - 10.2174/157489106775244055
M3 - Review article
C2 - 18221133
AN - SCOPUS:34748891739
SN - 1574-891X
VL - 1
SP - 45
EP - 55
JO - Recent patents on anti-infective drug discovery
JF - Recent patents on anti-infective drug discovery
IS - 1
ER -