Recent advances in flavivirus antiviral drug discovery and vaccine development.

Debashish Ray, Pei Yong Shi

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalRecent patents on anti-infective drug discovery
Volume1
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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