Recent advances in neurodegenerative disease research

Ekta Singh, Rahul Dilawari

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The global health-care crisis of neurodegenerative diseases is increasing due to limitations in efficacious therapy, which is unable to meet the demand of the rising number of cases. This challenging situation in pharmacotherapy has led to an urgent shift toward research and clinical trials for the development of novel therapeutics, modalities, and tools that target a wide range of neurodegenerative diseases in a holistic way. Current research is focused on targeting protein aggregation, neuronal damage, mitochondrial dysfunction, and neuroinflammation. Recently, there has been significant advancement in understanding the pathophysiological mechanisms underlying neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. This has enabled the discovery of various novel neuroprotective agents. In this chapter, we focus on recent advancements in the biology of neurodegenerative diseases, followed by neuroprotective strategies.

Original languageEnglish (US)
Title of host publicationThe Neurodegeneration Revolution
Subtitle of host publicationEmerging Therapies and Sustainable Solutions
PublisherElsevier
Pages527-548
Number of pages22
ISBN (Electronic)9780443288227
ISBN (Print)9780443288234
DOIs
StatePublished - Jan 1 2024
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Huntington's disease
  • Multiple sclerosis
  • Neurodegenerative diseases
  • Neuroinflammation
  • Neuroprotective agents
  • Parkinson's disease
  • Protein aggregation

ASJC Scopus subject areas

  • General Psychology

Fingerprint

Dive into the research topics of 'Recent advances in neurodegenerative disease research'. Together they form a unique fingerprint.

Cite this