Abstract
The global health-care crisis of neurodegenerative diseases is increasing due to limitations in efficacious therapy, which is unable to meet the demand of the rising number of cases. This challenging situation in pharmacotherapy has led to an urgent shift toward research and clinical trials for the development of novel therapeutics, modalities, and tools that target a wide range of neurodegenerative diseases in a holistic way. Current research is focused on targeting protein aggregation, neuronal damage, mitochondrial dysfunction, and neuroinflammation. Recently, there has been significant advancement in understanding the pathophysiological mechanisms underlying neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. This has enabled the discovery of various novel neuroprotective agents. In this chapter, we focus on recent advancements in the biology of neurodegenerative diseases, followed by neuroprotective strategies.
Original language | English (US) |
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Title of host publication | The Neurodegeneration Revolution |
Subtitle of host publication | Emerging Therapies and Sustainable Solutions |
Publisher | Elsevier |
Pages | 527-548 |
Number of pages | 22 |
ISBN (Electronic) | 9780443288227 |
ISBN (Print) | 9780443288234 |
DOIs | |
State | Published - Jan 1 2024 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Huntington's disease
- Multiple sclerosis
- Neurodegenerative diseases
- Neuroinflammation
- Neuroprotective agents
- Parkinson's disease
- Protein aggregation
ASJC Scopus subject areas
- General Psychology