Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection

Colm Atkins, Alexander Freiberg

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus endemic to sub-Saharan Africa and the Arabian Peninsula and the etiological agent of Rift Valley fever. Rift Valley fever is a disease of major public health and economic concern, affecting livestock and humans. In ruminants, RVFV infection is characterized by high mortality rates in newborns and near 100% abortion rates in pregnant animals. Infection in humans is typically manifested as a self-limiting febrile illness, but can lead to severe and fatal hepatitis, encephalitis, hemorrhagic fever or retinitis with partial or complete blindness. Currently, there are no specific treatment options available for RVFV infection. This review presents a summary of the therapeutic approaches that have been explored on the treatment of RVFV infection.

Original languageEnglish (US)
Pages (from-to)651-665
Number of pages15
JournalFuture Virology
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Rift Valley fever virus
Virus Diseases
Antiviral Agents
Rift Valley Fever
Fever
Orthobunyavirus
Retinitis
Induced Abortion
Africa South of the Sahara
Ruminants
Livestock
Encephalitis
Blindness
Therapeutics
Culicidae
Hepatitis
Public Health
Economics
Mortality
Infection

Keywords

  • antivirals
  • broad-spectrum
  • bunyavirus
  • high-throughput screen
  • Rift Valley fever virus
  • small molecules

ASJC Scopus subject areas

  • Virology

Cite this

Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection. / Atkins, Colm; Freiberg, Alexander.

In: Future Virology, Vol. 12, No. 11, 01.11.2017, p. 651-665.

Research output: Contribution to journalReview article

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