Recent advances in the diagnosis and treatment of central nervous system germ-cell tumours

Barkat Hooda, Jonathan L. Finlay

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-opthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biopsy allow precise anatomic definition, but only allow an approximate guess of the tumor histopathology. Tumor markers in the serum and cerebrospinal fluid are extremely helpful in the diagnosis and monitoring of response to treatment when they are detectable. Because of the deleterious effects of irradiation on neurocognitive and neuroendocrine functioning, we have looked at strategies that either reduce or eliminate radiation exposure. Large, randomized, prospective, cooperative trials in the future will be the only way to identify subgroups of patients that may benefit from particular treatment strategies. (C) 1999 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalCurrent Opinion in Neurology
Volume12
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Nervous System Neoplasms
Germ Cell and Embryonal Neoplasms
Central Nervous System
Central Nervous System Neoplasms
Tumor Biomarkers
Cerebrospinal Fluid
Age Groups
Pediatrics
Biopsy
Therapeutics
Serum
Neoplasms
Radiation Exposure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Recent advances in the diagnosis and treatment of central nervous system germ-cell tumours. / Hooda, Barkat; Finlay, Jonathan L.

In: Current Opinion in Neurology, Vol. 12, No. 6, 1999, p. 693-696.

Research output: Contribution to journalArticle

@article{d75ce24900ed431cb7eeb19dd14e3f1d,
title = "Recent advances in the diagnosis and treatment of central nervous system germ-cell tumours",
abstract = "Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-opthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biopsy allow precise anatomic definition, but only allow an approximate guess of the tumor histopathology. Tumor markers in the serum and cerebrospinal fluid are extremely helpful in the diagnosis and monitoring of response to treatment when they are detectable. Because of the deleterious effects of irradiation on neurocognitive and neuroendocrine functioning, we have looked at strategies that either reduce or eliminate radiation exposure. Large, randomized, prospective, cooperative trials in the future will be the only way to identify subgroups of patients that may benefit from particular treatment strategies. (C) 1999 Lippincott Williams and Wilkins.",
author = "Barkat Hooda and Finlay, {Jonathan L.}",
year = "1999",
doi = "10.1097/00019052-199912000-00006",
language = "English (US)",
volume = "12",
pages = "693--696",
journal = "Current Opinion in Neurology",
issn = "1350-7540",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Recent advances in the diagnosis and treatment of central nervous system germ-cell tumours

AU - Hooda, Barkat

AU - Finlay, Jonathan L.

PY - 1999

Y1 - 1999

N2 - Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-opthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biopsy allow precise anatomic definition, but only allow an approximate guess of the tumor histopathology. Tumor markers in the serum and cerebrospinal fluid are extremely helpful in the diagnosis and monitoring of response to treatment when they are detectable. Because of the deleterious effects of irradiation on neurocognitive and neuroendocrine functioning, we have looked at strategies that either reduce or eliminate radiation exposure. Large, randomized, prospective, cooperative trials in the future will be the only way to identify subgroups of patients that may benefit from particular treatment strategies. (C) 1999 Lippincott Williams and Wilkins.

AB - Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-opthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biopsy allow precise anatomic definition, but only allow an approximate guess of the tumor histopathology. Tumor markers in the serum and cerebrospinal fluid are extremely helpful in the diagnosis and monitoring of response to treatment when they are detectable. Because of the deleterious effects of irradiation on neurocognitive and neuroendocrine functioning, we have looked at strategies that either reduce or eliminate radiation exposure. Large, randomized, prospective, cooperative trials in the future will be the only way to identify subgroups of patients that may benefit from particular treatment strategies. (C) 1999 Lippincott Williams and Wilkins.

UR - http://www.scopus.com/inward/record.url?scp=0033375337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033375337&partnerID=8YFLogxK

U2 - 10.1097/00019052-199912000-00006

DO - 10.1097/00019052-199912000-00006

M3 - Article

VL - 12

SP - 693

EP - 696

JO - Current Opinion in Neurology

JF - Current Opinion in Neurology

SN - 1350-7540

IS - 6

ER -