Recent developments in West Nile virus vaccine and antiviral therapy

Anh N. Woodmansee, Pei Yong Shi

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

West Nile virus (WNV) is a mosquito-borne flavivirus that is now posing a severe threat to public health in North America. Prevention and treatment of WNV and other emerging flaviviruses represent a global public health priority. This article will review (i) general features of WNV transmission and replication (ii) strategies recently reported in the literature and patents for vaccine development against WNV infections and (iii) inhibitors reported to have anti-WNV activities. A number of approaches for antiviral drug discovery as well as strategies for improvement of the diagnosis of WNV infections are also suggested.

Original languageEnglish (US)
Pages (from-to)1113-1125
Number of pages13
JournalExpert Opinion on Therapeutic Patents
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Antiviral therapy
  • Arbovirus
  • Clinical diagnosis
  • Flavivirus
  • Vaccine
  • West Nile virus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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