Recent molecular insights into rickettsial pathogenesis and immunity

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Human infections with arthropod-borne Rickettsia species remain a major global health issue, causing significant morbidity and mortality. Epidemic typhus due to Rickettsia prowazekii has an established reputation as the 'scourge of armies', and as a major determinant of significant 'historical turning points'. No suitable vaccines for human use are currently available to prevent rickettsial diseases. The unique lifestyle features of rickettsiae include obligate intracellular parasitism, intracytoplasmic niche within the host cell, predilection for infection of microvascular endothelium in mammalian hosts, association with arthropods and the tendency for genomic reduction. The fundamental research in the field of Rickettsiology has witnessed significant recent progress in the areas of pathogen adhesion/invasion and host immune responses, as well as the genomics, proteomics, metabolomics, phylogenetics, motility and molecular manipulation of important rickettsial pathogens. The focus of this review article is to capture a snapshot of the latest developments pertaining to the mechanisms of rickettsial pathogenesis and immunity.

Original languageEnglish (US)
Pages (from-to)1265-1288
Number of pages24
JournalFuture Microbiology
Volume8
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Rickettsia
Arthropods
Immunity
Rickettsia prowazekii
Epidemic Louse-Borne Typhus
Metabolomics
Genomics
Infection
Proteomics
Endothelium
Life Style
Vaccines
Morbidity
Mortality
Research
Global Health
resmethrin

Keywords

  • endothelium
  • genomics
  • innate immunity
  • metabolomics
  • pathogenesis
  • plasmids
  • proteomics
  • Rickettsia
  • spotted fever
  • typhus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Recent molecular insights into rickettsial pathogenesis and immunity. / Sahni, Sanjeev; Narra, Hema P.; Sahni, Abha; Walker, David.

In: Future Microbiology, Vol. 8, No. 10, 10.2013, p. 1265-1288.

Research output: Contribution to journalArticle

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