Receptor-initiated activation of cells and their oncogenes by herpes-family viruses

Thomas Albrecht, Istvan Boldogh, Michael P. Fons

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The interaction of human cytomegalovirus (HCMV) with the cell membrane has been shown to initiate a cascade of physiologic and biochemical responses that result in the transcriptional activation of specific cellular proto-oncogenes. The cell-activation responses initiated by the virus membrane interaction appear to be important for efficient HCMV replication, as pharmacologic inhibition of cell activation responses significantly reduces the expression of immediate early viral genes and the production of infectious progeny virus. Cellular receptor proteins for other viruses have been shown to be molecules with physiologic activities. Binding of virus to these receptors may trigger the cell to initiate changes that are important for efficient viral replication. These viruses may also trigger inappropriate physiologic responses in the absence of viral replication, thereby causing more covert manifestations of viral pathology.

Original languageEnglish (US)
Pages (from-to)S29-S35
JournalJournal of Investigative Dermatology
Volume98
Issue number6 SUPPL.
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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