Receptor localization in the mammalian dorsal horn and primary afferent neurons

Richard E. Coggeshall, Susan M. Carlton

Research output: Contribution to journalReview article

210 Scopus citations

Abstract

The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

Original languageEnglish (US)
Pages (from-to)28-66
Number of pages39
JournalBrain Research Reviews
Volume24
Issue number1
DOIs
StatePublished - Jun 1 1997

Keywords

  • Amino acid
  • Nociception
  • Pain
  • Peptide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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