Receptor localization in the mammalian dorsal horn and primary afferent neurons

Richard E. Coggeshall, Susan M. Carlton

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

Original languageEnglish (US)
Pages (from-to)28-66
Number of pages39
JournalBrain Research Reviews
Volume24
Issue number1
DOIs
StatePublished - Jun 1997

Fingerprint

Afferent Neurons
Substantia Gelatinosa
Somatosensory Cortex
Nervous System
Spinal Cord Dorsal Horn

Keywords

  • Amino acid
  • Nociception
  • Pain
  • Peptide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Receptor localization in the mammalian dorsal horn and primary afferent neurons. / Coggeshall, Richard E.; Carlton, Susan M.

In: Brain Research Reviews, Vol. 24, No. 1, 06.1997, p. 28-66.

Research output: Contribution to journalArticle

Coggeshall, Richard E. ; Carlton, Susan M. / Receptor localization in the mammalian dorsal horn and primary afferent neurons. In: Brain Research Reviews. 1997 ; Vol. 24, No. 1. pp. 28-66.
@article{21ffdb86310f4e6f9e0c5f007fc31b1e,
title = "Receptor localization in the mammalian dorsal horn and primary afferent neurons",
abstract = "The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.",
keywords = "Amino acid, Nociception, Pain, Peptide",
author = "Coggeshall, {Richard E.} and Carlton, {Susan M.}",
year = "1997",
month = "6",
doi = "10.1016/S0165-0173(97)00010-6",
language = "English (US)",
volume = "24",
pages = "28--66",
journal = "Brain Research Reviews",
issn = "0165-0173",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Receptor localization in the mammalian dorsal horn and primary afferent neurons

AU - Coggeshall, Richard E.

AU - Carlton, Susan M.

PY - 1997/6

Y1 - 1997/6

N2 - The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

AB - The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

KW - Amino acid

KW - Nociception

KW - Pain

KW - Peptide

UR - http://www.scopus.com/inward/record.url?scp=0030848141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030848141&partnerID=8YFLogxK

U2 - 10.1016/S0165-0173(97)00010-6

DO - 10.1016/S0165-0173(97)00010-6

M3 - Article

C2 - 9233541

AN - SCOPUS:0030848141

VL - 24

SP - 28

EP - 66

JO - Brain Research Reviews

JF - Brain Research Reviews

SN - 0165-0173

IS - 1

ER -