Receptors for insulin and IGF-I in bovine lens epithelium

A. C. Sinha, C. A. Stuart, S. K. Srivastava

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The presence of insulin receptors has not yet been established in lens epithelial cells. Our goal was to understand the involvement of insulin in lens pathology, especially diabetic cataractogenesis. As a first step in this process, we evaluated the presence of insulin receptors in bovine lens epithelium. Insulin bound to insulin receptor with a high affinity (K(D) 53.7 nM). SDS-PAGE and subsequent autoradiography of affinity labeled insulin receptor show the presence of a 130 kDa band, indicating that the lens epithelium insulin receptor may be similar to insulin receptors isolated from other tissues.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalLens and Eye Toxicity Research
Volume7
Issue number2
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    Sinha, A. C., Stuart, C. A., & Srivastava, S. K. (1990). Receptors for insulin and IGF-I in bovine lens epithelium. Lens and Eye Toxicity Research, 7(2), 133-141.