Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin

John M. Thomas; Scott T. Moen; Bryan T. Gnade; Diego A. Vargas-Inchaustegui; Sheri M. Foltz; Giovanni Suarez; Hans W. Heidner; Rolf König; Ashok K. Chopra; Johnny W. Peterson

doi:10.1128/CVI.00173-09

Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin

John M. Thomas, Scott T. Moen, Bryan T. Gnade, Diego A. Vargas-Inchaustegui, Sheri M. Foltz, Giovanni Suarez, Hans W. Heidner, Rolf König, Ashok K. Chopra, Johnny W. Peterson

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

Original language	English (US)
Pages (from-to)	1696-1699
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	16
Issue number	11
DOIs	https://doi.org/10.1128/CVI.00173-09
State	Published - Nov 2009

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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Thomas, J. M., Moen, S. T., Gnade, B. T., Vargas-Inchaustegui, D. A., Foltz, S. M., Suarez, G., Heidner, H. W., König, R., Chopra, A. K., & Peterson, J. W. (2009). Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin. Clinical and Vaccine Immunology, 16(11), 1696-1699. https://doi.org/10.1128/CVI.00173-09

Thomas, JM, Moen, ST, Gnade, BT, Vargas-Inchaustegui, DA, Foltz, SM, Suarez, G, Heidner, HW, König, R, Chopra, AK & Peterson, JW 2009, 'Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin', Clinical and Vaccine Immunology, vol. 16, no. 11, pp. 1696-1699. https://doi.org/10.1128/CVI.00173-09

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AU - Vargas-Inchaustegui, Diego A.

AU - Foltz, Sheri M.

AU - Suarez, Giovanni

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Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin

Abstract

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