Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin

John M. Thomas, Scott T. Moen, Bryan T. Gnade, Diego A. Vargas-Inchaustegui, Sheri M. Foltz, Giovanni Suarez, Hans W. Heidner, Rolf König, Ashok Chopra, Johnny Peterson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

Original languageEnglish (US)
Pages (from-to)1696-1699
Number of pages4
JournalClinical and Vaccine Immunology
Volume16
Issue number11
DOIs
StatePublished - Nov 2009

Fingerprint

Sindbis Virus
Anthrax
Ciprofloxacin
Viruses
Animals
Display devices
Neutralizing Antibodies
Spores
Immunity
Vaccination
Immunoglobulin G
Antigens
anthrax toxin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin. / Thomas, John M.; Moen, Scott T.; Gnade, Bryan T.; Vargas-Inchaustegui, Diego A.; Foltz, Sheri M.; Suarez, Giovanni; Heidner, Hans W.; König, Rolf; Chopra, Ashok; Peterson, Johnny.

In: Clinical and Vaccine Immunology, Vol. 16, No. 11, 11.2009, p. 1696-1699.

Research output: Contribution to journalArticle

Thomas, John M. ; Moen, Scott T. ; Gnade, Bryan T. ; Vargas-Inchaustegui, Diego A. ; Foltz, Sheri M. ; Suarez, Giovanni ; Heidner, Hans W. ; König, Rolf ; Chopra, Ashok ; Peterson, Johnny. / Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin. In: Clinical and Vaccine Immunology. 2009 ; Vol. 16, No. 11. pp. 1696-1699.
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