Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin

John M. Thomas, Scott T. Moen, Bryan T. Gnade, Diego A. Vargas-Inchaustegui, Sheri M. Foltz, Giovanni Suarez, Hans W. Heidner, Rolf Konig, Ashok K. Chopra, Johnny W. Peterson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

Original languageEnglish (US)
Pages (from-to)1696-1699
Number of pages4
JournalClinical and Vaccine Immunology
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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  • Cite this

    Thomas, J. M., Moen, S. T., Gnade, B. T., Vargas-Inchaustegui, D. A., Foltz, S. M., Suarez, G., Heidner, H. W., Konig, R., Chopra, A. K., & Peterson, J. W. (2009). Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin. Clinical and Vaccine Immunology, 16(11), 1696-1699. https://doi.org/10.1128/CVI.00173-09