Abstract
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
Original language | English (US) |
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Pages (from-to) | 1696-1699 |
Number of pages | 4 |
Journal | Clinical and Vaccine Immunology |
Volume | 16 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2009 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Clinical Biochemistry
- Microbiology (medical)