Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

R. M. Kinney, J. J. Esposito, J. H. Mathews, B. J B Johnson, J. T. Roehrig, Alan Barrett, D. W. Trent

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

Original languageEnglish (US)
Pages (from-to)4697-4702
Number of pages6
JournalJournal of Virology
Volume62
Issue number12
StatePublished - 1988
Externally publishedYes

Fingerprint

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
Venezuelan Equine Encephalomyelitides
Vaccinia virus
encephalitis
Trinidad and Tobago
mice
horses
Equidae
asses
Viruses
viruses
Immunization
immunization
Vaccines
Horse Diseases
vaccines
Capsid Proteins
aerosols
Neutralizing Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Kinney, R. M., Esposito, J. J., Mathews, J. H., Johnson, B. J. B., Roehrig, J. T., Barrett, A., & Trent, D. W. (1988). Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. Journal of Virology, 62(12), 4697-4702.

Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. / Kinney, R. M.; Esposito, J. J.; Mathews, J. H.; Johnson, B. J B; Roehrig, J. T.; Barrett, Alan; Trent, D. W.

In: Journal of Virology, Vol. 62, No. 12, 1988, p. 4697-4702.

Research output: Contribution to journalArticle

Kinney, RM, Esposito, JJ, Mathews, JH, Johnson, BJB, Roehrig, JT, Barrett, A & Trent, DW 1988, 'Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge', Journal of Virology, vol. 62, no. 12, pp. 4697-4702.
Kinney, R. M. ; Esposito, J. J. ; Mathews, J. H. ; Johnson, B. J B ; Roehrig, J. T. ; Barrett, Alan ; Trent, D. W. / Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. In: Journal of Virology. 1988 ; Vol. 62, No. 12. pp. 4697-4702.
@article{7b9f9e11fe6541ac8475274f07086345,
title = "Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge",
abstract = "Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.",
author = "Kinney, {R. M.} and Esposito, {J. J.} and Mathews, {J. H.} and Johnson, {B. J B} and Roehrig, {J. T.} and Alan Barrett and Trent, {D. W.}",
year = "1988",
language = "English (US)",
volume = "62",
pages = "4697--4702",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "12",

}

TY - JOUR

T1 - Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

AU - Kinney, R. M.

AU - Esposito, J. J.

AU - Mathews, J. H.

AU - Johnson, B. J B

AU - Roehrig, J. T.

AU - Barrett, Alan

AU - Trent, D. W.

PY - 1988

Y1 - 1988

N2 - Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

AB - Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

UR - http://www.scopus.com/inward/record.url?scp=0024209356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024209356&partnerID=8YFLogxK

M3 - Article

VL - 62

SP - 4697

EP - 4702

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 12

ER -