Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge

R. M. Kinney, J. J. Esposito, J. H. Mathews, B. J.B. Johnson, J. T. Roehrig, A. D.T. Barrett, D. W. Trent

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus.

Original languageEnglish (US)
Pages (from-to)4697-4702
Number of pages6
JournalJournal of virology
Volume62
Issue number12
StatePublished - Dec 1 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Kinney, R. M., Esposito, J. J., Mathews, J. H., Johnson, B. J. B., Roehrig, J. T., Barrett, A. D. T., & Trent, D. W. (1988). Recombinant vaccinia virus /Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. Journal of virology, 62(12), 4697-4702.