Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates

Thomas Geisbert, Kathleen M. Daddario-DiCaprio, Kinola J N Williams, Joan B. Geisbert, Anders Leung, Friederike Feldmann, Lisa E. Hensley, Heinz Feldmann, Steven M. Jones

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can partially protect macaques after challenge with Zaire ebolavirus. Here, we administered a VSV vector expressing the Sudan ebolavirus (SEBOV) glycoprotein to four rhesus macaques shortly after exposure to SEBOV. All four animals survived SEBOV challenge, while a control animal that received a nonspecific vector developed fulminant SEBOV hemorrhagic fever and succumbed. This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses.

Original languageEnglish (US)
Pages (from-to)5664-5668
Number of pages5
JournalJournal of Virology
Volume82
Issue number11
DOIs
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Sudan Ebola virus
Ebola Hemorrhagic Fever
Ebolavirus
Vesiculovirus
Vesicular Stomatitis
Sudan
Primates
fever
Viruses
Macaca mulatta
Zaire Ebola virus
glycoproteins
Marburg virus
Filoviridae
Glycoproteins
Marburgvirus
Macaca
Democratic Republic of the Congo
animals
vaccination

ASJC Scopus subject areas

  • Immunology

Cite this

Geisbert, T., Daddario-DiCaprio, K. M., Williams, K. J. N., Geisbert, J. B., Leung, A., Feldmann, F., ... Jones, S. M. (2008). Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates. Journal of Virology, 82(11), 5664-5668. https://doi.org/10.1128/JVI.00456-08

Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates. / Geisbert, Thomas; Daddario-DiCaprio, Kathleen M.; Williams, Kinola J N; Geisbert, Joan B.; Leung, Anders; Feldmann, Friederike; Hensley, Lisa E.; Feldmann, Heinz; Jones, Steven M.

In: Journal of Virology, Vol. 82, No. 11, 06.2008, p. 5664-5668.

Research output: Contribution to journalArticle

Geisbert, T, Daddario-DiCaprio, KM, Williams, KJN, Geisbert, JB, Leung, A, Feldmann, F, Hensley, LE, Feldmann, H & Jones, SM 2008, 'Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates', Journal of Virology, vol. 82, no. 11, pp. 5664-5668. https://doi.org/10.1128/JVI.00456-08
Geisbert, Thomas ; Daddario-DiCaprio, Kathleen M. ; Williams, Kinola J N ; Geisbert, Joan B. ; Leung, Anders ; Feldmann, Friederike ; Hensley, Lisa E. ; Feldmann, Heinz ; Jones, Steven M. / Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates. In: Journal of Virology. 2008 ; Vol. 82, No. 11. pp. 5664-5668.
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