Abstract
The proposed recommendation for measuring and reporting chloride in undiluted plasma† or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.
Original language | English (US) |
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Pages (from-to) | 346-352 |
Number of pages | 7 |
Journal | Clinical Chemistry and Laboratory Medicine |
Volume | 44 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2006 |
Keywords
- Blood
- Chloride (ionized and total)
- Coulometry
- Ion-selective electrode
- Plasma
- Standardization
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical