Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood

Mohammed C. Ben Rayana, Robert W. Burnett, Arthur K. Covington, Paul D'Orazio, Niels Fogh-Andersen, Ellis Jacobs, Ritu Kataky, Wolf R. Külpmann, Katsuhiko Kuwa, Lasse Larsson, Andrzej Lewenstam, Anton H.J. Maas, Gerhard Mager, Jerzy W. Naskalski, Anthony O. Okorodudu, Christoph Ritter, Andrew St John

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Issue number3
StatePublished - Mar 1 2006
Externally publishedYes


  • Blood
  • Chloride (ionized and total)
  • Coulometry
  • Ion-selective electrode
  • Plasma
  • Standardization

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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