Recommendations and choices for BRCA mutation carriers at risk for ovarian cancer: A complicated decision

Kelsey E. Lewis, Karen H. Lu, Amber M. Klimczak, Samuel C. Mok

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Current ovarian cancer screening guidelines in high-risk women vary according to different organizations. Risk reducing surgery remains the gold standard for definitive treatment in BRCA mutation carriers, but research advancements have created more short-term options for patients to consider. The decisions involved in how a woman manages her BRCA mutation status can cause a great deal of stress and worry due to the imperfect therapy options. The goal of this review was to critically analyze the screening recommendations and alternative options for high-risk ovarian cancer patients and evaluate how these discrepancies and choices affect a woman’s management decisions.

Original languageEnglish (US)
Article number57
JournalCancers
Volume10
Issue number2
DOIs
StatePublished - Feb 21 2018

Keywords

  • BRCA
  • CA-125
  • Ovarian cancer
  • Risk-reducing surgery
  • Screening guidelines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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