Recommendations for preventing the spread of vancomycin resistance

Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC)

Walter J. Hierholzer, Julia S. Garner, Audrey B. Adams, Donald E. Craven, David W. Fleming, Susan W. Forlenza, Mary J. Gilchrist, Donald A. Goldmann, Elaine L. Larson, C. Glen Mayhall, Rita D. McCormick, Ronald L. Nichols

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

A rapid increase in the incidence of infection and colonization with vancomycin-resistant enterococci (VRE) has been reported from U.S. hospitals in the last 5 years. This increase poses several problems, including a) the lack of available antimicrobials for therapy of infections due to VRE, since most VRE are also resistant to multiple other drugs, e.g., aminoglycosides and ampicillin, previously used for the treatment of infections due to these organisms, and b) the possibility that the vancomycin resistance genes present in VRE may be transferred to other gram-positive microorganisms such as Staphylococcus aureus. An increased risk of VRE infection and colonization has been associated with previous vancomycin and/or multi-antimicrobial therapy, severe underlying disease or immunosuppression, and intra-abdominal surgery. Because enterococci can be found in the normal gastrointestinal or female genital tract, most enterococcal infections have been attributed to endogenous sources within the individual patient. However, recent reports of outbreaks and endemic infections due to enterococci, including VRE, have shown that patient-to-patient transmission of the microorganisms can occur either via direct contact or indirectly via hands of personnel or contaminated patient-care equipment or environmental surfaces. Prevention and control of the spread of vancomycin resistance will require coordinated, concerted effort from variotis departments of the hospital, and can only be achieved if each of the following elements is addressed: 1) prudent vancomycin use by clinicians, 2) education of hospital staff regarding the problem of vancomycin resistance, 3) early detection and prompt reporting of vancomycin resistance in enterococci and other gram-positive microorganisms by the hospital microbiology laboratory, and 4) immediate implementation of appropriate infection-control measures to prevent personto-person transmission of VRE.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalAmerican Journal of Infection Control
Volume23
Issue number2
DOIs
StatePublished - 1995

Fingerprint

Vancomycin Resistance
Advisory Committees
Infection Control
Cross Infection
Enterococcus
Infection
Vancomycin
Hospital Laboratories
Hospital Departments
Aminoglycosides
Ampicillin
Microbiology
Vancomycin-Resistant Enterococci
Immunosuppression
Disease Outbreaks
Staphylococcus aureus
Patient Care
Therapeutics
Hand
Education

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Recommendations for preventing the spread of vancomycin resistance : Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). / Hierholzer, Walter J.; Garner, Julia S.; Adams, Audrey B.; Craven, Donald E.; Fleming, David W.; Forlenza, Susan W.; Gilchrist, Mary J.; Goldmann, Donald A.; Larson, Elaine L.; Mayhall, C. Glen; McCormick, Rita D.; Nichols, Ronald L.

In: American Journal of Infection Control, Vol. 23, No. 2, 1995, p. 87-94.

Research output: Contribution to journalArticle

Hierholzer, WJ, Garner, JS, Adams, AB, Craven, DE, Fleming, DW, Forlenza, SW, Gilchrist, MJ, Goldmann, DA, Larson, EL, Mayhall, CG, McCormick, RD & Nichols, RL 1995, 'Recommendations for preventing the spread of vancomycin resistance: Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC)', American Journal of Infection Control, vol. 23, no. 2, pp. 87-94. https://doi.org/10.1016/0196-6553(95)90104-3
Hierholzer, Walter J. ; Garner, Julia S. ; Adams, Audrey B. ; Craven, Donald E. ; Fleming, David W. ; Forlenza, Susan W. ; Gilchrist, Mary J. ; Goldmann, Donald A. ; Larson, Elaine L. ; Mayhall, C. Glen ; McCormick, Rita D. ; Nichols, Ronald L. / Recommendations for preventing the spread of vancomycin resistance : Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). In: American Journal of Infection Control. 1995 ; Vol. 23, No. 2. pp. 87-94.
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abstract = "A rapid increase in the incidence of infection and colonization with vancomycin-resistant enterococci (VRE) has been reported from U.S. hospitals in the last 5 years. This increase poses several problems, including a) the lack of available antimicrobials for therapy of infections due to VRE, since most VRE are also resistant to multiple other drugs, e.g., aminoglycosides and ampicillin, previously used for the treatment of infections due to these organisms, and b) the possibility that the vancomycin resistance genes present in VRE may be transferred to other gram-positive microorganisms such as Staphylococcus aureus. An increased risk of VRE infection and colonization has been associated with previous vancomycin and/or multi-antimicrobial therapy, severe underlying disease or immunosuppression, and intra-abdominal surgery. Because enterococci can be found in the normal gastrointestinal or female genital tract, most enterococcal infections have been attributed to endogenous sources within the individual patient. However, recent reports of outbreaks and endemic infections due to enterococci, including VRE, have shown that patient-to-patient transmission of the microorganisms can occur either via direct contact or indirectly via hands of personnel or contaminated patient-care equipment or environmental surfaces. Prevention and control of the spread of vancomycin resistance will require coordinated, concerted effort from variotis departments of the hospital, and can only be achieved if each of the following elements is addressed: 1) prudent vancomycin use by clinicians, 2) education of hospital staff regarding the problem of vancomycin resistance, 3) early detection and prompt reporting of vancomycin resistance in enterococci and other gram-positive microorganisms by the hospital microbiology laboratory, and 4) immediate implementation of appropriate infection-control measures to prevent personto-person transmission of VRE.",
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