Reconstruction of the mandible for osteoradionecrosis

Kareem Haroun, Orly M. Coblens

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Purpose of reviewTo describe current standard of care for osteoradionecrosis (ORN) of the mandible and report possible future trends.Recent findingsCutting guides may be used to reduce surgical time and possibly improve outcomes. There has also been recent investigation into the use of pentoxifylline and tocopherol or pentoxifylline, tocopherol and clodronate (a well known conservative medial regime) as a prevention for development of ORN after dental extractions and the first randomized controlled study is upcoming. Augmented reality has shown promise as a comparable and inexpensive possible alternative to cutting guides.SummaryCurrent standard of care involves conservative/supportive therapy with antioxidants, antibiotics, steroids, and pain control for low-grade ORN with surgery reserved for high-grade/progressive ORN with refractory to conservative therapy and with significant oral dysfunction.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number5
StatePublished - Oct 1 2019


  • hyperbaric oxygen
  • mandibular osteoradionecrosis
  • mandibular reconstruction
  • pentoxifylline and tocopherol or pentoxifylline, tocopherol and clodronate

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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