Recovery from the hepatic acute phase response in the severely burned and the effects of long-term growth hormone treatment

Suchmor Thomas, Steven Wolf, David L. Chinkes, David Herndon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Administration of growth hormone (GH) to burned children decreases acute phase proteins and increases constitutive proteins when used during the acute hospitalization. Treatment during convalescence has not been examined. Methods: Seventy-six children with total body surface area burned (TBSAB) ≥40% were randomized to either placebo or GH (0.05 mg/kg/day) from discharge to 1 year after burn. Subjects were followed for an additional year. Levels of constitutive proteins and acute phase proteins were measured at discharge and 6, 9, 12, 18, and 24 months. Data are expressed as mean±S.E.M. Results: Albumin and transferrin levels increased during convalescence to the normal range but pre-albumin and retinol binding protein (RBP) levels remained below normal for at least 24 months. Acute phase proteins α1-acid glycoprotein, C-reactive protein, and haptoglobin decreased (P<0.05) but α2-macroglobulin increased from discharge to 6 months. C-3 complement remained elevated for at least 2 years after burn. Changes were similar in both groups with no effect for GH treatment. Conclusion: Some hepatic acute phase and constitutive proteins remain abnormal even 2 years after injury. GH treatment during convalescence has no effect on hepatic acute phase protein changes.

Original languageEnglish (US)
Pages (from-to)675-679
Number of pages5
JournalBurns
Volume30
Issue number7
DOIs
StatePublished - Nov 2004

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Acute-Phase Reaction
Acute-Phase Proteins
Growth Hormone
Liver
Albumins
Therapeutics
Retinol-Binding Proteins
Macroglobulins
Complement C3
Haptoglobins
Body Surface Area
Transferrin
C-Reactive Protein
Reference Values
Proteins
Hospitalization
Placebos
Acids
Wounds and Injuries

Keywords

  • α-Acid glycoprotein
  • α-Macroglobulin (α-MAC)
  • Acute phase proteins
  • Albumin
  • Constitutive proteins
  • Growth hormone (GH)
  • Haptoglobin
  • Pre-albumin
  • Retinol binding protein (RBP)
  • Transferrin

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Recovery from the hepatic acute phase response in the severely burned and the effects of long-term growth hormone treatment. / Thomas, Suchmor; Wolf, Steven; Chinkes, David L.; Herndon, David.

In: Burns, Vol. 30, No. 7, 11.2004, p. 675-679.

Research output: Contribution to journalArticle

Thomas, Suchmor ; Wolf, Steven ; Chinkes, David L. ; Herndon, David. / Recovery from the hepatic acute phase response in the severely burned and the effects of long-term growth hormone treatment. In: Burns. 2004 ; Vol. 30, No. 7. pp. 675-679.
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