Recruitment of ipsilateral and contralateral upper limb muscles following stimulation of the cortical motor areas in the monkey

Lynnette R. Montgomery, Wendy J. Herbert, John A. Buford

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    It is well established that cortical motor stimulation results in contralateral upper limb (UL) activity. Motor responses are also elicited in the ipsilateral UL, though controversy surrounds the significance of these effects. Evidence suggests that ipsilateral muscle activity is more common following the stimulation of the supplementary motor area (SMA) and dorsal premotor area (PMd), compared to the primary motor cortex (M1), but none of these studies compared effects from all three areas in the same subjects. This has limited our understanding of how these three cortical motor areas influence ipsilateral UL muscle activity. The purpose of this study was to determine the contribution of each of three cortical areas to the production of ipsilateral and contralateral UL. To maximize sensitivity and allow comparison of the effects across cortical areas, we applied the same stimulation parameters (36 pulse stimulus train at 330 Hz) to M1, SMA, and PMd in three adult M. fascicularis and recorded electromyographic (EMG) activity from muscles in the trunk and both ULs. Of all muscle responses identified, 24 % were ipsilateral to the stimulation, mostly in proximal muscles. The highest percentage of ipsilateral responses occurred following SMA stimulation. We also observed that PMd stimulation elicited more suppression responses compared with stimulation of M1 and SMA. The results indicate that ipsilateral motor areas provide a significant contribution to cortical activation of the trunk and proximal UL muscles. These understudied pathways may represent a functional substrate for future strategies to shape UL recovery following injury or stroke.

    Original languageEnglish
    Pages (from-to)153-164
    Number of pages12
    JournalExperimental Brain Research
    Volume230
    Issue number2
    DOIs
    StatePublished - Oct 2013

    Fingerprint

    Motor Cortex
    Upper Extremity
    Haplorhini
    Muscles
    Stroke
    Wounds and Injuries

    Keywords

    • Corticospinal
    • Motor control
    • Reaching
    • Stimulus trains

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Recruitment of ipsilateral and contralateral upper limb muscles following stimulation of the cortical motor areas in the monkey. / Montgomery, Lynnette R.; Herbert, Wendy J.; Buford, John A.

    In: Experimental Brain Research, Vol. 230, No. 2, 10.2013, p. 153-164.

    Research output: Contribution to journalArticle

    Montgomery, Lynnette R. ; Herbert, Wendy J. ; Buford, John A. / Recruitment of ipsilateral and contralateral upper limb muscles following stimulation of the cortical motor areas in the monkey. In: Experimental Brain Research. 2013 ; Vol. 230, No. 2. pp. 153-164.
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