TY - JOUR
T1 - Recurrent Nodular Fasciitis of the Oral Mucosa
T2 - Case Report and Review of the Literature
AU - Ovechko, Vasily
AU - Peterson, Joshua M.
AU - Hasan, Hasanain
AU - Yi, Christopher
AU - Throndson, Roger
AU - Qiu, Suimin
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Among all benign and reactive mesenchymal lesions, nodular fasciitis is most frequently misdiagnosed as a sarcoma due to its concerning clinical and histopathological features: it arises on fascial surfaces, grows rapidly, and may infiltrate into adjacent tissues and blood vessels. The most commonly involved sites include upper extremities, trunk, head, and neck, with rare occurrences in the oral cavity. Recurrences following both incomplete and complete excision are rare, and its natural history progresses through self-limited growth followed by spontaneous regression. Herein we present a rapidly growing nodular fasciitis of the buccal mucosa confirmed by molecular testing for USP6 gene rearrangements which recurred 3 weeks following complete surgical excision. Additionally, we review reports of oral cavity nodular fasciitis between 2011 and 2023. Increasing awareness and diagnostic accuracy of this benign mimicker of oral cavity malignancy will help prevent unnecessary radical surgical resections.
AB - Among all benign and reactive mesenchymal lesions, nodular fasciitis is most frequently misdiagnosed as a sarcoma due to its concerning clinical and histopathological features: it arises on fascial surfaces, grows rapidly, and may infiltrate into adjacent tissues and blood vessels. The most commonly involved sites include upper extremities, trunk, head, and neck, with rare occurrences in the oral cavity. Recurrences following both incomplete and complete excision are rare, and its natural history progresses through self-limited growth followed by spontaneous regression. Herein we present a rapidly growing nodular fasciitis of the buccal mucosa confirmed by molecular testing for USP6 gene rearrangements which recurred 3 weeks following complete surgical excision. Additionally, we review reports of oral cavity nodular fasciitis between 2011 and 2023. Increasing awareness and diagnostic accuracy of this benign mimicker of oral cavity malignancy will help prevent unnecessary radical surgical resections.
KW - head and neck sarcoma
KW - mucosal nodular fasciitis
KW - nodular fasciitis
KW - oral neoplasm
KW - oral nodular fasciitis
KW - recurrent nodular fasciitis
KW - sarcoma mimicker
KW - sarcoma misdiagnosis
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U2 - 10.1177/10668969241297258
DO - 10.1177/10668969241297258
M3 - Article
C2 - 39552462
AN - SCOPUS:85209353642
SN - 1066-8969
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
ER -