Recurrent tuberculosis in Houston, Texas

A population-based study

H. M. El Sahly, J. A. Wright, H. Soini, T. T. Bui, Natalie Williams-Bouyer, P. Escalante, J. M. Musser, Edward A. Graviss

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE: To determine the predictors of recurrence of tuberculosis (TB), the drug resistance pattern of Mycobacterium tuberculosis strains recovered from recurrent TB patients, and the frequency of re-infection with a new M. tuberculosis strain among patients with recurrent disease. DESIGN: A population-based, retrospective case-control study using the Houston Tuberculosis Initiative database. RESULTS: We found that, among 100 patients with recurrent TB who completed adequate therapy for a first episode of TB, not receiving directly observed therapy, pulmonary disease, HIV/AIDS diagnosis, not having a family physician, being unemployed and using public transportation were predictors of recurrent disease. There was a significant increase in drug-resistant M. tuberculosis strains in the second episode of disease compared to the first episode (21.3% vs. 8.2%, P = 0.04). Exogenous re-infection with a new strain of M. tuberculosis was found to cause 24-31% of recurrent TB. CONCLUSION: Recurrent TB in Houston is associated with a significant increase in drug-resistant M. tuberculosis strains. Re-infection with a new M. tuberculosis strain causes a significant proportion of recurrent TB in an area of low TB incidence. Patients with HIV/AIDS constitute a population at increased risk of disease recurrence.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume8
Issue number3
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Tuberculosis
Population
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
Mycobacterium
Acquired Immunodeficiency Syndrome
Infection
Directly Observed Therapy
HIV
Recurrence
Family Physicians
Drug Resistance
Lung Diseases
Case-Control Studies
Databases
Incidence

Keywords

  • Genotyping
  • Molecular epidemiology
  • Reinfection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

El Sahly, H. M., Wright, J. A., Soini, H., Bui, T. T., Williams-Bouyer, N., Escalante, P., ... Graviss, E. A. (2004). Recurrent tuberculosis in Houston, Texas: A population-based study. International Journal of Tuberculosis and Lung Disease, 8(3), 333-340.

Recurrent tuberculosis in Houston, Texas : A population-based study. / El Sahly, H. M.; Wright, J. A.; Soini, H.; Bui, T. T.; Williams-Bouyer, Natalie; Escalante, P.; Musser, J. M.; Graviss, Edward A.

In: International Journal of Tuberculosis and Lung Disease, Vol. 8, No. 3, 03.2004, p. 333-340.

Research output: Contribution to journalArticle

El Sahly, HM, Wright, JA, Soini, H, Bui, TT, Williams-Bouyer, N, Escalante, P, Musser, JM & Graviss, EA 2004, 'Recurrent tuberculosis in Houston, Texas: A population-based study', International Journal of Tuberculosis and Lung Disease, vol. 8, no. 3, pp. 333-340.
El Sahly, H. M. ; Wright, J. A. ; Soini, H. ; Bui, T. T. ; Williams-Bouyer, Natalie ; Escalante, P. ; Musser, J. M. ; Graviss, Edward A. / Recurrent tuberculosis in Houston, Texas : A population-based study. In: International Journal of Tuberculosis and Lung Disease. 2004 ; Vol. 8, No. 3. pp. 333-340.
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