Recurrent vascular thrombosis in an adolescent transplant recipient

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Vascular thrombosis is one of the more difficult problems of pediatric renal transplantation; its etiology is multifactorial and, in most cases, it is irreversible. Vascular thrombosis accounts for 12.9% of graft failures in primary transplants in children and for 20% of graft failures in repeat transplants. Although it is seen most often in very young recipients and in recipients of kidneys from young donors, it can manifest in older children and adolescents as well. The peak incidence is seen in the first 48 h after transplantation; however, the event may be delayed until after the first week. When thrombosis occurs in an adolescent patient late in the course of transplantation, the pathogenesis is undetermined and immunosuppressive therapy is frequently implicated. This article describes a 19-yr-old patient with a three-antigen-matched cadaveric kidney who received cyclosporine and anti-thymocyte globulin for induction. Vascular thrombosis occurred after 7 d of initial good function. Eventually the graft was removed after attempts to re-establish vascularization failed. The patient received a second graft and despite an optimal six-antigen match and different immunosuppression with tacrolimus, thrombosis recurred by the fifth postoperative day. The discussion that follows reviews the incidence and the factors implicated in the pathogenesis of this entity.

Original languageEnglish (US)
Pages (from-to)1477-1482
Number of pages6
JournalJournal of the American Society of Nephrology
Volume8
Issue number9
StatePublished - Sep 1997
Externally publishedYes

Fingerprint

Blood Vessels
Thrombosis
Transplants
Transplantation
Kidney
Antigens
Antilymphocyte Serum
Incidence
Tacrolimus
Immunosuppressive Agents
Kidney Transplantation
Immunosuppression
Cyclosporine
Transplant Recipients
Tissue Donors
Pediatrics

ASJC Scopus subject areas

  • Nephrology

Cite this

Recurrent vascular thrombosis in an adolescent transplant recipient. / Balachandra, Shivaiah; Tejani, Amir.

In: Journal of the American Society of Nephrology, Vol. 8, No. 9, 09.1997, p. 1477-1482.

Research output: Contribution to journalArticle

@article{5919802b294d4f5792648afcff518693,
title = "Recurrent vascular thrombosis in an adolescent transplant recipient",
abstract = "Vascular thrombosis is one of the more difficult problems of pediatric renal transplantation; its etiology is multifactorial and, in most cases, it is irreversible. Vascular thrombosis accounts for 12.9{\%} of graft failures in primary transplants in children and for 20{\%} of graft failures in repeat transplants. Although it is seen most often in very young recipients and in recipients of kidneys from young donors, it can manifest in older children and adolescents as well. The peak incidence is seen in the first 48 h after transplantation; however, the event may be delayed until after the first week. When thrombosis occurs in an adolescent patient late in the course of transplantation, the pathogenesis is undetermined and immunosuppressive therapy is frequently implicated. This article describes a 19-yr-old patient with a three-antigen-matched cadaveric kidney who received cyclosporine and anti-thymocyte globulin for induction. Vascular thrombosis occurred after 7 d of initial good function. Eventually the graft was removed after attempts to re-establish vascularization failed. The patient received a second graft and despite an optimal six-antigen match and different immunosuppression with tacrolimus, thrombosis recurred by the fifth postoperative day. The discussion that follows reviews the incidence and the factors implicated in the pathogenesis of this entity.",
author = "Shivaiah Balachandra and Amir Tejani",
year = "1997",
month = "9",
language = "English (US)",
volume = "8",
pages = "1477--1482",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "9",

}

TY - JOUR

T1 - Recurrent vascular thrombosis in an adolescent transplant recipient

AU - Balachandra, Shivaiah

AU - Tejani, Amir

PY - 1997/9

Y1 - 1997/9

N2 - Vascular thrombosis is one of the more difficult problems of pediatric renal transplantation; its etiology is multifactorial and, in most cases, it is irreversible. Vascular thrombosis accounts for 12.9% of graft failures in primary transplants in children and for 20% of graft failures in repeat transplants. Although it is seen most often in very young recipients and in recipients of kidneys from young donors, it can manifest in older children and adolescents as well. The peak incidence is seen in the first 48 h after transplantation; however, the event may be delayed until after the first week. When thrombosis occurs in an adolescent patient late in the course of transplantation, the pathogenesis is undetermined and immunosuppressive therapy is frequently implicated. This article describes a 19-yr-old patient with a three-antigen-matched cadaveric kidney who received cyclosporine and anti-thymocyte globulin for induction. Vascular thrombosis occurred after 7 d of initial good function. Eventually the graft was removed after attempts to re-establish vascularization failed. The patient received a second graft and despite an optimal six-antigen match and different immunosuppression with tacrolimus, thrombosis recurred by the fifth postoperative day. The discussion that follows reviews the incidence and the factors implicated in the pathogenesis of this entity.

AB - Vascular thrombosis is one of the more difficult problems of pediatric renal transplantation; its etiology is multifactorial and, in most cases, it is irreversible. Vascular thrombosis accounts for 12.9% of graft failures in primary transplants in children and for 20% of graft failures in repeat transplants. Although it is seen most often in very young recipients and in recipients of kidneys from young donors, it can manifest in older children and adolescents as well. The peak incidence is seen in the first 48 h after transplantation; however, the event may be delayed until after the first week. When thrombosis occurs in an adolescent patient late in the course of transplantation, the pathogenesis is undetermined and immunosuppressive therapy is frequently implicated. This article describes a 19-yr-old patient with a three-antigen-matched cadaveric kidney who received cyclosporine and anti-thymocyte globulin for induction. Vascular thrombosis occurred after 7 d of initial good function. Eventually the graft was removed after attempts to re-establish vascularization failed. The patient received a second graft and despite an optimal six-antigen match and different immunosuppression with tacrolimus, thrombosis recurred by the fifth postoperative day. The discussion that follows reviews the incidence and the factors implicated in the pathogenesis of this entity.

UR - http://www.scopus.com/inward/record.url?scp=0030825892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030825892&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 1477

EP - 1482

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 9

ER -