Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007

Stephen P. Luby, M. Jahangir Hossain, Emily S. Gurley, Be Nazir Ahmed, Shakila Banu, Salah Uddin Khan, Nusrat Homaira, Paul A. Rota, Pierre E. Rollin, James A. Comer, Eben Kenah, Thomas Ksiazek, Mahmudur Rahman

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Human Nipah outbreaks recur in a specific region and time of year in Bangladesh. Fruit bats are the reservoir host for Nipah virus. We identified 23 introductions of Nipah virus into human populations in central and northwestern Bangladesh from 2001 through 2007. Ten introductions affected multiple persons (median 10). Illness onset occurred from December through May but not every year. We identified 122 cases of human Nipah infection. The mean age of case-patients was 27 years; 87 (71%) died. In 62 (51%) Nipah virus-infected patients, illness developed 5-15 days after close contact with another Nipah case-patient. Nine (7%) Nipah case-patients transmitted virus to others. Nipah case-patients who had difficulty breathing were more likely than those without respiratory difficulty to transmit Nipah (12% vs. 0%, p = 0.03). Although a small minority of infected patients transmit Nipah virus, more than half of identified cases result from person-to-person transmission. Interventions to prevent virus transmission from bats to humans and from person to person are needed.

Original languageEnglish (US)
Pages (from-to)1229-1235
Number of pages7
JournalEmerging Infectious Diseases
Volume15
Issue number8
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Nipah Virus
Bangladesh
Zoonoses
Viruses
Disease Outbreaks
Fruit
Respiration
Infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Luby, S. P., Hossain, M. J., Gurley, E. S., Ahmed, B. N., Banu, S., Khan, S. U., ... Rahman, M. (2009). Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. Emerging Infectious Diseases, 15(8), 1229-1235. https://doi.org/10.3201/eid1508.081237

Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. / Luby, Stephen P.; Hossain, M. Jahangir; Gurley, Emily S.; Ahmed, Be Nazir; Banu, Shakila; Khan, Salah Uddin; Homaira, Nusrat; Rota, Paul A.; Rollin, Pierre E.; Comer, James A.; Kenah, Eben; Ksiazek, Thomas; Rahman, Mahmudur.

In: Emerging Infectious Diseases, Vol. 15, No. 8, 08.2009, p. 1229-1235.

Research output: Contribution to journalArticle

Luby, SP, Hossain, MJ, Gurley, ES, Ahmed, BN, Banu, S, Khan, SU, Homaira, N, Rota, PA, Rollin, PE, Comer, JA, Kenah, E, Ksiazek, T & Rahman, M 2009, 'Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007', Emerging Infectious Diseases, vol. 15, no. 8, pp. 1229-1235. https://doi.org/10.3201/eid1508.081237
Luby, Stephen P. ; Hossain, M. Jahangir ; Gurley, Emily S. ; Ahmed, Be Nazir ; Banu, Shakila ; Khan, Salah Uddin ; Homaira, Nusrat ; Rota, Paul A. ; Rollin, Pierre E. ; Comer, James A. ; Kenah, Eben ; Ksiazek, Thomas ; Rahman, Mahmudur. / Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. In: Emerging Infectious Diseases. 2009 ; Vol. 15, No. 8. pp. 1229-1235.
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