Redness response phenotypes of allergic conjunctivitis in an allergen challenge chamber

Robert L. Jacobs, Daniel A. Ramirez, Cynthia G. Rather, Charles P. Andrews, Daniel Jupiter, Fernando Trujillo, David G. Shulman

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations


    Background There are few direct data concerning symptom dynamics of allergic conjunctivitis (AC) in an allergen challenge chamber (ACC). Objective To determine the AC dynamics on subsequent exposures to ragweed pollen (RW) in individuals with allergic rhinitis in an ACC. To determine whether consecutive exposures in an ACC have any persistent detrimental ocular physical effects. Methods Participants underwent 3 exposures to RW in an ACC. Ocular symptoms of itching and tearing were self-assessed. Ocular redness and lid swelling were assessed by trained ophthalmic technicians. Complete ophthalmic examinations (COEs) were performed by an ophthalmologist. Results A total of 188 of 201 participants (93%) developed an ocular redness score of 2 or more in each eye in ACC exposure 1. Reproducibility of redness occurred in approximately 70% of individuals completing ACC exposures 1 through 3. There were no significant changes between baseline COE and end of study COE. Phenotypes were identified by redness responses during and after exposure. Baseline total ocular symptom scores, at 24 hours after a priming exposure, were identified as late-phase reactions rather than enhanced sensitivity. Conclusion When assessed by trained professionals, AC was present with a very high frequency in selected individuals allergic to RW monitored in an ACC. Intrasubject reproducibility of redness was consistent across 3 ACC allergen exposures. Phenotypes were identified as early-phase responses, protracted early-phase responses, dual responses, and late-phase responses. Trial Registration Identifier: NCT02079649.

    Original languageEnglish (US)
    Pages (from-to)86-93.e2
    JournalAnnals of Allergy, Asthma and Immunology
    Issue number1
    StatePublished - Jan 1 2017

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Pulmonary and Respiratory Medicine


    Dive into the research topics of 'Redness response phenotypes of allergic conjunctivitis in an allergen challenge chamber'. Together they form a unique fingerprint.

    Cite this