Reduced Body Weight and Adiposity with a High-Protein Diet Improves Functional Status, Lipid Profiles, Glycemic Control, and Quality of Life in Patients with Heart Failure: A Feasibility Study

Lorraine Evangelista, David Heber, Zhaoping Li, Susan Bowerman, Michele A. Hamilton, Gregg C. Fonarow

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

BACKGROUND:: The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known. OBJECTIVE:: This feasibility study was conducted to evaluate the impact of 3 dietary interventions on body weight and adiposity, functional status, lipid profiles, glycemic control, and quality of life (QOL) in overweight and obese patients with HF and type 2 diabetes mellitus. DESIGN:: Fourteen patients with HF with a body mass index greater than 27 kg/m were randomized to an HP diet, a standard protein diet, or a conventional diet. Data were obtained at baseline and 12 weeks. RESULTS:: There were no significant differences in age (59 ± 10 years), sex (78% male), New York Heart Association class (43% class II, 57% class III), and HF etiology or left ventricular ejection fraction (26 ± 7) between the groups at baseline. Patients on the HP diet demonstrated significantly greater reductions in weight (P = .005), percent body fat (P = .036), total cholesterol (P = .016), triglyceride concentrations (P = .034), and low-density lipoprotein cholesterol (P = .041) and greater improvements in functional status (6-minute walk [P = .010] and VO2 peak [P = .003]), high-density lipoprotein cholesterol (P = .006), and physical QOL scores (P = .022) compared with those on standard protein and conventional diets. CONCLUSION:: A 12-week HP diet resulted in moderate weight loss and reduced adiposity in a small sample of overweight and obese patients with HF that were associated with improvements in functional status, lipid profiles, glycemic control, and QOL. However, these preliminary findings must be confirmed in studies with more participants and long-term follow-up.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalJournal of Cardiovascular Nursing
Volume24
Issue number3
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Adiposity
Feasibility Studies
Heart Failure
Body Weight
Quality of Life
Diet
Lipids
Proteins
Weight Loss
Reducing Diet
compound A 12
Stroke Volume
LDL Cholesterol
Type 2 Diabetes Mellitus
HDL Cholesterol
Adipose Tissue
Triglycerides
Body Mass Index
Cholesterol

Keywords

  • Heart failure
  • High-protein diet
  • Quality of life
  • Weight reduction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Reduced Body Weight and Adiposity with a High-Protein Diet Improves Functional Status, Lipid Profiles, Glycemic Control, and Quality of Life in Patients with Heart Failure : A Feasibility Study. / Evangelista, Lorraine; Heber, David; Li, Zhaoping; Bowerman, Susan; Hamilton, Michele A.; Fonarow, Gregg C.

In: Journal of Cardiovascular Nursing, Vol. 24, No. 3, 01.05.2009, p. 207-215.

Research output: Contribution to journalArticle

@article{4ca5817240c74e0395704afb591c4923,
title = "Reduced Body Weight and Adiposity with a High-Protein Diet Improves Functional Status, Lipid Profiles, Glycemic Control, and Quality of Life in Patients with Heart Failure: A Feasibility Study",
abstract = "BACKGROUND:: The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known. OBJECTIVE:: This feasibility study was conducted to evaluate the impact of 3 dietary interventions on body weight and adiposity, functional status, lipid profiles, glycemic control, and quality of life (QOL) in overweight and obese patients with HF and type 2 diabetes mellitus. DESIGN:: Fourteen patients with HF with a body mass index greater than 27 kg/m were randomized to an HP diet, a standard protein diet, or a conventional diet. Data were obtained at baseline and 12 weeks. RESULTS:: There were no significant differences in age (59 ± 10 years), sex (78{\%} male), New York Heart Association class (43{\%} class II, 57{\%} class III), and HF etiology or left ventricular ejection fraction (26 ± 7) between the groups at baseline. Patients on the HP diet demonstrated significantly greater reductions in weight (P = .005), percent body fat (P = .036), total cholesterol (P = .016), triglyceride concentrations (P = .034), and low-density lipoprotein cholesterol (P = .041) and greater improvements in functional status (6-minute walk [P = .010] and VO2 peak [P = .003]), high-density lipoprotein cholesterol (P = .006), and physical QOL scores (P = .022) compared with those on standard protein and conventional diets. CONCLUSION:: A 12-week HP diet resulted in moderate weight loss and reduced adiposity in a small sample of overweight and obese patients with HF that were associated with improvements in functional status, lipid profiles, glycemic control, and QOL. However, these preliminary findings must be confirmed in studies with more participants and long-term follow-up.",
keywords = "Heart failure, High-protein diet, Quality of life, Weight reduction",
author = "Lorraine Evangelista and David Heber and Zhaoping Li and Susan Bowerman and Hamilton, {Michele A.} and Fonarow, {Gregg C.}",
year = "2009",
month = "5",
day = "1",
doi = "10.1097/JCN.0b013e31819846b9",
language = "English (US)",
volume = "24",
pages = "207--215",
journal = "Journal of Cardiovascular Nursing",
issn = "0889-4655",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Reduced Body Weight and Adiposity with a High-Protein Diet Improves Functional Status, Lipid Profiles, Glycemic Control, and Quality of Life in Patients with Heart Failure

T2 - A Feasibility Study

AU - Evangelista, Lorraine

AU - Heber, David

AU - Li, Zhaoping

AU - Bowerman, Susan

AU - Hamilton, Michele A.

AU - Fonarow, Gregg C.

PY - 2009/5/1

Y1 - 2009/5/1

N2 - BACKGROUND:: The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known. OBJECTIVE:: This feasibility study was conducted to evaluate the impact of 3 dietary interventions on body weight and adiposity, functional status, lipid profiles, glycemic control, and quality of life (QOL) in overweight and obese patients with HF and type 2 diabetes mellitus. DESIGN:: Fourteen patients with HF with a body mass index greater than 27 kg/m were randomized to an HP diet, a standard protein diet, or a conventional diet. Data were obtained at baseline and 12 weeks. RESULTS:: There were no significant differences in age (59 ± 10 years), sex (78% male), New York Heart Association class (43% class II, 57% class III), and HF etiology or left ventricular ejection fraction (26 ± 7) between the groups at baseline. Patients on the HP diet demonstrated significantly greater reductions in weight (P = .005), percent body fat (P = .036), total cholesterol (P = .016), triglyceride concentrations (P = .034), and low-density lipoprotein cholesterol (P = .041) and greater improvements in functional status (6-minute walk [P = .010] and VO2 peak [P = .003]), high-density lipoprotein cholesterol (P = .006), and physical QOL scores (P = .022) compared with those on standard protein and conventional diets. CONCLUSION:: A 12-week HP diet resulted in moderate weight loss and reduced adiposity in a small sample of overweight and obese patients with HF that were associated with improvements in functional status, lipid profiles, glycemic control, and QOL. However, these preliminary findings must be confirmed in studies with more participants and long-term follow-up.

AB - BACKGROUND:: The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known. OBJECTIVE:: This feasibility study was conducted to evaluate the impact of 3 dietary interventions on body weight and adiposity, functional status, lipid profiles, glycemic control, and quality of life (QOL) in overweight and obese patients with HF and type 2 diabetes mellitus. DESIGN:: Fourteen patients with HF with a body mass index greater than 27 kg/m were randomized to an HP diet, a standard protein diet, or a conventional diet. Data were obtained at baseline and 12 weeks. RESULTS:: There were no significant differences in age (59 ± 10 years), sex (78% male), New York Heart Association class (43% class II, 57% class III), and HF etiology or left ventricular ejection fraction (26 ± 7) between the groups at baseline. Patients on the HP diet demonstrated significantly greater reductions in weight (P = .005), percent body fat (P = .036), total cholesterol (P = .016), triglyceride concentrations (P = .034), and low-density lipoprotein cholesterol (P = .041) and greater improvements in functional status (6-minute walk [P = .010] and VO2 peak [P = .003]), high-density lipoprotein cholesterol (P = .006), and physical QOL scores (P = .022) compared with those on standard protein and conventional diets. CONCLUSION:: A 12-week HP diet resulted in moderate weight loss and reduced adiposity in a small sample of overweight and obese patients with HF that were associated with improvements in functional status, lipid profiles, glycemic control, and QOL. However, these preliminary findings must be confirmed in studies with more participants and long-term follow-up.

KW - Heart failure

KW - High-protein diet

KW - Quality of life

KW - Weight reduction

UR - http://www.scopus.com/inward/record.url?scp=67650327202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650327202&partnerID=8YFLogxK

U2 - 10.1097/JCN.0b013e31819846b9

DO - 10.1097/JCN.0b013e31819846b9

M3 - Article

C2 - 19390338

AN - SCOPUS:67650327202

VL - 24

SP - 207

EP - 215

JO - Journal of Cardiovascular Nursing

JF - Journal of Cardiovascular Nursing

SN - 0889-4655

IS - 3

ER -