Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage

Elena Titova, Robert P. Ostrowski, Christopher G. Kevil, Wenni Tong, Hugo Rojas, Lawrence C. Sowers, John H. Zhang, Jiping Tang

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Many studies have indicated leukocytes are a major contributor to brain injuries caused by intracerebral hemorrhage (ICH). Leukocyte-expressed CD18 is important for neutrophil-endothelial interactions in the vasculature, and CD18 deficiency protects against ischemia-reperfusion injury. We investigated whether CD18 deficiency provides protection against ICH-induced brain injury. Male wild-type (WT) CD18+/+ mice and CD18-/- -knockout mice were used in this study. ICH was induced by a collagenase injection. Mortality, neurological function, brain edema, and myeloperoxidase (MPO) activity as well as tissue expression of nitrotyrosine and MPO were evaluated 24 hr after ICH. We discovered significantly reduced brain edema and diminished mortality with a concomitant decrease in MPO and nitrøtyrosine immunoreactivity in brains of CD18-knockout mice. _cd 2008 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)3240-3245
Number of pages6
JournalJournal of Neuroscience Research
Volume86
Issue number14
DOIs
StatePublished - Dec 8 2008
Externally publishedYes

Keywords

  • Brain edema
  • CD18 mice
  • Collagenase
  • Inflammation
  • Intracerebral hemorrhage

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Titova, E., Ostrowski, R. P., Kevil, C. G., Tong, W., Rojas, H., Sowers, L. C., Zhang, J. H., & Tang, J. (2008). Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage. Journal of Neuroscience Research, 86(14), 3240-3245. https://doi.org/10.1002/jnr.21762