Reduction in telomere length in individuals exposed in utero to glycol ether

Randa El-Zein, Thomas Albrecht, Eugene Knutson, Marvin S. Legator, Sherif Abdel-Rahman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Little is known about the mechanism by which ethylene glycol monomethyl ether (EGME) produces genotoxic effects in humans. The authors found that individuals exposed in utero to EGME showed characteristic dysmorphic features, unexplained mental retardation, and persistent cytogenetic damage. They hypothesized that these individuals had a higher level of terminal chromosome arrangements, accounting for the genomic instability detected. Results indicate that in utero-exposed individuals have significantly reduced telomeres relative to non-in utero-exposed participants. The M ± SEM pixel intensity in the in utero-exposed participants was 43.6 ± 7.6 compared with 74.1 ± 1.9 in the non-in utero-exposed. Findings suggest that exposure to EGME in utero could result in terminal chromosome rearrangements and shortening of telomere length, leading to the observed dysmorphic features and idiopathic mental retardation.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalArchives of Environmental and Occupational Health
Volume62
Issue number3
StatePublished - 2007

Fingerprint

Glycols
Telomere
ether
Ether
ethylene
Chromosomes
Intellectual Disability
chromosome
Telomere Shortening
Genomic Instability
cytogenetics
Cytogenetics
genomics
pixel
Pixels
scanning electron microscopy
Scanning electron microscopy
damage
methyl cellosolve

Keywords

  • Birth defects
  • Chemical exposure
  • Children

ASJC Scopus subject areas

  • Environmental Science(all)
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Public Health, Environmental and Occupational Health

Cite this

Reduction in telomere length in individuals exposed in utero to glycol ether. / El-Zein, Randa; Albrecht, Thomas; Knutson, Eugene; Legator, Marvin S.; Abdel-Rahman, Sherif.

In: Archives of Environmental and Occupational Health, Vol. 62, No. 3, 2007, p. 161-163.

Research output: Contribution to journalArticle

El-Zein, Randa ; Albrecht, Thomas ; Knutson, Eugene ; Legator, Marvin S. ; Abdel-Rahman, Sherif. / Reduction in telomere length in individuals exposed in utero to glycol ether. In: Archives of Environmental and Occupational Health. 2007 ; Vol. 62, No. 3. pp. 161-163.
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