TY - JOUR
T1 - Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase
AU - He, Qin
AU - Khanna, Peeyush
AU - Srivastava, Sanjay
AU - Van Kuijk, Frederik J.G.M.
AU - Ansari, Naseem H.
N1 - Funding Information:
This study was partially supported by NIH Grant EY 08547, the Lions Eye Bank Foundation, and Texas Higher Education. The authors thank Ms. Terry Campbell for typing the manuscript.
PY - 1998/6/29
Y1 - 1998/6/29
N2 - Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.
AB - Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.
UR - http://www.scopus.com/inward/record.url?scp=0032577943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032577943&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1998.8845
DO - 10.1006/bbrc.1998.8845
M3 - Article
C2 - 9647760
AN - SCOPUS:0032577943
SN - 0006-291X
VL - 247
SP - 719
EP - 722
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -