Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

Qin He, Peeyush Khanna, Sanjay Srivastava, Frederik J.G.M. Van Kuijk, Naseem H. Ansari

    Research output: Contribution to journalArticlepeer-review

    30 Scopus citations

    Abstract

    Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.

    Original languageEnglish (US)
    Pages (from-to)719-722
    Number of pages4
    JournalBiochemical and Biophysical Research Communications
    Volume247
    Issue number3
    DOIs
    StatePublished - Jun 29 1998

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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