Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

Qin He; Peeyush Khanna; Sanjay Srivastava; Frederik J.G.M. Van Kuijk; Naseem H. Ansari

doi:10.1006/bbrc.1998.8845

Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

Qin He
, Peeyush Khanna
, Sanjay Srivastava
, Frederik J.G.M. Van Kuijk
, Naseem H. Ansari

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.

Original language	English (US)
Pages (from-to)	719-722
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	247
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.1998.8845
State	Published - Jun 29 1998
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1998.8845

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title = "Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase",

abstract = "Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.",

author = "Qin He and Peeyush Khanna and Sanjay Srivastava and \{Van Kuijk\}, \{Frederik J.G.M.\} and Ansari, \{Naseem H.\}",

note = "Funding Information: This study was partially supported by NIH Grant EY 08547, the Lions Eye Bank Foundation, and Texas Higher Education. The authors thank Ms. Terry Campbell for typing the manuscript.",

year = "1998",

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doi = "10.1006/bbrc.1998.8845",

language = "English (US)",

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TY - JOUR

T1 - Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

AU - He, Qin

AU - Khanna, Peeyush

AU - Srivastava, Sanjay

AU - Van Kuijk, Frederik J.G.M.

AU - Ansari, Naseem H.

N1 - Funding Information: This study was partially supported by NIH Grant EY 08547, the Lions Eye Bank Foundation, and Texas Higher Education. The authors thank Ms. Terry Campbell for typing the manuscript.

PY - 1998/6/29

Y1 - 1998/6/29

N2 - Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.

AB - Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal, the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.

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DO - 10.1006/bbrc.1998.8845

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AN - SCOPUS:0032577943

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Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

Abstract

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