Reduction of morbidity and mortality from biliary complications after liver transplantation

Andrew S. Klein, Scott Savader, James F. Burdick, Jeffrey Fair, Mack Mitchell, Paul Colombani, Bruce Perler, Floyd Osterman, G. Melville Williams

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Over a 4-yr period that began October 1, 1986, 103 orthotopic liver transplants were performed on 91 patients at the Johns Hopkins Hospital. Biliary reconstruction at the time of transplantation was performed in standard fashion by an appropriately trained member of the surgical team. Six (7%) patients developed biliary complications, which included three cases of common bile duct stricture and one case each of bile duct obstruction caused by biopsy-related hemobilia, biloma and a retained fragment of a T tube after removal. Five of the six patients were treated successfully by nonoperative interventional radiological procedures performed under local anesthesia with light intravenous sedation. Reoperative surgery (to remove the T-tube fragment from subcutaneous tissue) was required for only one patient, and no deaths (0 of 91) were attributable to biliary complications. All six patients are alive and well 6 to 33 mo after the operation with excellent liver function. Our findings would suggest that most biliary complications of orthotopic liver transplants are avoidable and that the few that do appear can usually be managed both safely and effectively by an interventional radiological approach.

Original languageEnglish (US)
Pages (from-to)818-823
Number of pages6
JournalHepatology
Volume14
Issue number5
StatePublished - Nov 1991
Externally publishedYes

Fingerprint

Liver Transplantation
Morbidity
Mortality
Liver
Hemobilia
Transplants
Cholestasis
Subcutaneous Tissue
Common Bile Duct
Local Anesthesia
Pathologic Constriction
Transplantation
Biopsy
Light

ASJC Scopus subject areas

  • Hepatology

Cite this

Klein, A. S., Savader, S., Burdick, J. F., Fair, J., Mitchell, M., Colombani, P., ... Williams, G. M. (1991). Reduction of morbidity and mortality from biliary complications after liver transplantation. Hepatology, 14(5), 818-823.

Reduction of morbidity and mortality from biliary complications after liver transplantation. / Klein, Andrew S.; Savader, Scott; Burdick, James F.; Fair, Jeffrey; Mitchell, Mack; Colombani, Paul; Perler, Bruce; Osterman, Floyd; Williams, G. Melville.

In: Hepatology, Vol. 14, No. 5, 11.1991, p. 818-823.

Research output: Contribution to journalArticle

Klein, AS, Savader, S, Burdick, JF, Fair, J, Mitchell, M, Colombani, P, Perler, B, Osterman, F & Williams, GM 1991, 'Reduction of morbidity and mortality from biliary complications after liver transplantation', Hepatology, vol. 14, no. 5, pp. 818-823.
Klein AS, Savader S, Burdick JF, Fair J, Mitchell M, Colombani P et al. Reduction of morbidity and mortality from biliary complications after liver transplantation. Hepatology. 1991 Nov;14(5):818-823.
Klein, Andrew S. ; Savader, Scott ; Burdick, James F. ; Fair, Jeffrey ; Mitchell, Mack ; Colombani, Paul ; Perler, Bruce ; Osterman, Floyd ; Williams, G. Melville. / Reduction of morbidity and mortality from biliary complications after liver transplantation. In: Hepatology. 1991 ; Vol. 14, No. 5. pp. 818-823.
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