(Re)emergence of A(H1N1)pdm09 influenza viruses with pandemic markers in the 2018/2019 flu season in the USA [version 1; peer review: 2 approved with reservations]

Slobodan Paessler; Veljko Veljkovic

doi:10.12688/F1000RESEARCH.17915.1

(Re)emergence of A(H1N1)pdm09 influenza viruses with pandemic markers in the 2018/2019 flu season in the USA [version 1; peer review: 2 approved with reservations]

Slobodan Paessler, Veljko Veljkovic

Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

During the 2009 pandemic, the Centers for Disease and Control and Prevention (CDC) estimated that 43 to 89 million cases of swine flu were reported during a 1-year span, with 1799 deaths in 178 countries worldwide. Now, nine years later, A(H1N1)pdm09 influenza viruses, which caused this pandemic, have reemerged and become the dominant subtype for the current 2018/19 flu season in the USA. The in silico analysis of A(H1N1)pdm09 viruses isolated in USA in October and November 2018, performed using the electronic biology platform “wEB”, showed that these viruses carry previously identified pandemic markers suggesting their increased pandemic potential. Possible consequences of these findings are discussed.

Original language	English (US)
Article number	141
Journal	F1000Research
Volume	8
DOIs	https://doi.org/10.12688/F1000RESEARCH.17915.1
State	Published - 2019

Keywords

Electronic biology
Influenza virus
Mutations
Pandemic
Swine flu

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.12688/F1000RESEARCH.17915.1

Cite this

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title = "(Re)emergence of A(H1N1)pdm09 influenza viruses with pandemic markers in the 2018/2019 flu season in the USA [version 1; peer review: 2 approved with reservations]",

abstract = "During the 2009 pandemic, the Centers for Disease and Control and Prevention (CDC) estimated that 43 to 89 million cases of swine flu were reported during a 1-year span, with 1799 deaths in 178 countries worldwide. Now, nine years later, A(H1N1)pdm09 influenza viruses, which caused this pandemic, have reemerged and become the dominant subtype for the current 2018/19 flu season in the USA. The in silico analysis of A(H1N1)pdm09 viruses isolated in USA in October and November 2018, performed using the electronic biology platform “wEB”, showed that these viruses carry previously identified pandemic markers suggesting their increased pandemic potential. Possible consequences of these findings are discussed.",

keywords = "Electronic biology, Influenza virus, Mutations, Pandemic, Swine flu",

author = "Slobodan Paessler and Veljko Veljkovic",

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year = "2019",

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language = "English (US)",

volume = "8",

journal = "F1000Research",

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T2 - 2 approved with reservations]

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PY - 2019

Y1 - 2019

N2 - During the 2009 pandemic, the Centers for Disease and Control and Prevention (CDC) estimated that 43 to 89 million cases of swine flu were reported during a 1-year span, with 1799 deaths in 178 countries worldwide. Now, nine years later, A(H1N1)pdm09 influenza viruses, which caused this pandemic, have reemerged and become the dominant subtype for the current 2018/19 flu season in the USA. The in silico analysis of A(H1N1)pdm09 viruses isolated in USA in October and November 2018, performed using the electronic biology platform “wEB”, showed that these viruses carry previously identified pandemic markers suggesting their increased pandemic potential. Possible consequences of these findings are discussed.

AB - During the 2009 pandemic, the Centers for Disease and Control and Prevention (CDC) estimated that 43 to 89 million cases of swine flu were reported during a 1-year span, with 1799 deaths in 178 countries worldwide. Now, nine years later, A(H1N1)pdm09 influenza viruses, which caused this pandemic, have reemerged and become the dominant subtype for the current 2018/19 flu season in the USA. The in silico analysis of A(H1N1)pdm09 viruses isolated in USA in October and November 2018, performed using the electronic biology platform “wEB”, showed that these viruses carry previously identified pandemic markers suggesting their increased pandemic potential. Possible consequences of these findings are discussed.

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(Re)emergence of A(H1N1)pdm09 influenza viruses with pandemic markers in the 2018/2019 flu season in the USA [version 1; peer review: 2 approved with reservations]

Abstract

Keywords

ASJC Scopus subject areas

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