Regional CNS uptake of blood-borne nerve growth factor

R. Loy, Giulio Taglialatela, L. Angelucci, D. Heyer, R. Perez-Polo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Nerve growth factor (NGF), in addition to being a neurotrophic substance, has effects on the endocrine and immune systems. For example, intravenous injection of NGF results in a cascade of events leading to an increase in glucocorticoid secretion. While this response appears to be mediated centrally, there has been no evidence that circulating NGF has access to the CNS. Using intravenous injections of 125I-NGF, we find specific uptake at 1 hr but none at 6 hr, into homogenates of the basal forebrain, cerebellum, frontal cortex, hippocampus, and olfactory bulb. By autoradiography, uptake is localized to circumventricular organs, deep layers of the cerebellum, and all layers of the hippocampal region CA1, but not the dentate gyrus. Thus, uptake of blood-borne NGF could affect the hypothalamic-pituitary-adrenal axis via binding to NGF receptors present in the hippocampus. However, the sources of endogenous NGF, the mechanism of access through the blood-brain barrier, the eventual fate of NGF entering from the blood, and the physiological significance of this uptake remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalJournal of Neuroscience Research
Volume39
Issue number3
DOIs
StatePublished - 1994

Fingerprint

Nerve Growth Factor
Intravenous Injections
Cerebellum
Hippocampus
Nerve Growth Factor Receptors
Hippocampal CA1 Region
Endocrine System
Olfactory Bulb
Dentate Gyrus
Frontal Lobe
Blood-Brain Barrier
Autoradiography
Glucocorticoids
Immune System

Keywords

  • blood-brain barrier
  • cerebellum
  • circumventricular organs
  • hippocampus
  • hypothalamic-pituitary-adrenal axis
  • stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Regional CNS uptake of blood-borne nerve growth factor. / Loy, R.; Taglialatela, Giulio; Angelucci, L.; Heyer, D.; Perez-Polo, R.

In: Journal of Neuroscience Research, Vol. 39, No. 3, 1994, p. 339-346.

Research output: Contribution to journalArticle

Loy, R. ; Taglialatela, Giulio ; Angelucci, L. ; Heyer, D. ; Perez-Polo, R. / Regional CNS uptake of blood-borne nerve growth factor. In: Journal of Neuroscience Research. 1994 ; Vol. 39, No. 3. pp. 339-346.
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