Regional differences in the regulation of contraction-relaxation machinery of vascular smooth muscle.

A. G. Kovach, E. Dora, M. Farago, I. H. Horvath, Csaba Szabo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the present study we revealed substantial differences in the regulation of the contraction-relaxation machinery of the middle cerebral and mesenteric arteries. a. Although K+-Krebs solution resulted in similar contractile responses in both vascular beds, norepinephrine, serotonin and PGF2 alpha were more potent in inducing contraction in the mesenteric artery than in the middle cerebral artery. Contrary, extremely high concentrations of acetylcholine produced negligible contractions in the mesenteric artery as compared to the middle cerebral artery. b. In more than 50% of the cases a considerable spontaneous tone developed in the middle cerebral artery, which was not due to the activation of adrenergic alpha receptors or some arachidonic acid metabolite. A similar phenomenon never occurred in the mesenteric artery. c. Acetylcholine, adenosine triphosphate and adenosine brought about similar dilatory concentration-response curves in the middle cerebral artery, but greatly different ones in the mesenteric artery where acetylcholine was the most, adenosine triphosphate the least potent dilator.

Original languageEnglish (US)
Pages (from-to)601-609
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume248
StatePublished - 1989
Externally publishedYes

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Mesenteric Arteries
Middle Cerebral Artery
Vascular Smooth Muscle
Acetylcholine
Machinery
Muscle
Adenosine Triphosphate
Receptors, Adrenergic, alpha
Dinoprost
Metabolites
Arachidonic Acid
Adenosine
Serotonin
Norepinephrine
Chemical activation
Blood Vessels

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regional differences in the regulation of contraction-relaxation machinery of vascular smooth muscle. / Kovach, A. G.; Dora, E.; Farago, M.; Horvath, I. H.; Szabo, Csaba.

In: Advances in Experimental Medicine and Biology, Vol. 248, 1989, p. 601-609.

Research output: Contribution to journalArticle

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