Regional lung function profiles of stage i and III lung cancer patients: An evaluation for functional avoidance radiation therapy

Yevgeniy Vinogradskiy, Leah Schubert, Quentin Diot, Timothy Waxweiller, Phillip Koo, Richard Castillo, Edward Castillo, Thomas Guerrero, Chad Rusthoven, Laurie Gaspar, Brian Kavanagh, Moyed Miften

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22 Scopus citations

Abstract

Purpose The development of clinical trials is underway to use 4-dimensional computed tomography (4DCT) ventilation imaging to preferentially spare functional lung in patients undergoing radiation therapy. The purpose of this work was to generate data to aide with clinical trial design by retrospectively characterizing dosimetric and functional profiles for patients with different stages of lung cancer. Methods and Materials A total of 118 lung cancer patients (36% stage I and 64% stage III) from 2 institutions were used for the study. A 4DCT-ventilation map was calculated using the patient's 4DCT imaging, deformable image registration, and a density-change-based algorithm. To assess each patient's spatial ventilation profile both quantitative and qualitative metrics were developed, including an observer-based defect observation and metrics based on the ventilation in each lung third. For each patient we used the clinical doses to calculate functionally weighted mean lung doses and metrics that assessed the interplay between the spatial location of the dose and high-functioning lung. Results Both qualitative and quantitative metrics revealed a significant difference in functional profiles between the 2 stage groups (P

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume95
Issue number4
DOIs
StatePublished - Jul 15 2016

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

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    Vinogradskiy, Y., Schubert, L., Diot, Q., Waxweiller, T., Koo, P., Castillo, R., Castillo, E., Guerrero, T., Rusthoven, C., Gaspar, L., Kavanagh, B., & Miften, M. (2016). Regional lung function profiles of stage i and III lung cancer patients: An evaluation for functional avoidance radiation therapy. International Journal of Radiation Oncology Biology Physics, 95(4), 1273-1280. https://doi.org/10.1016/j.ijrobp.2016.02.058