Regional therapies for in-transit disease

Paul J. Speicher, Claire H. Meriwether, Douglas S. Tyler

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


In-transit melanoma is an uncommon pattern of recurrence, but presents unique management challenges and opportunities for treatment. The clinical presentation usually involves from 1 to more than 100 small subcutaneous or cutaneous nodules, ranging from submillimeter to multiple centimeters in diameter. Regional chemotherapy techniques are a mainstay of treatment of patients without systemic disease spread. Future applications of regional therapy are likely to involve combination therapy with cytotoxic agents and novel immune modulators. Regional therapy provides distinct opportunities for the treatment of unresectable disease, and offers a unique platform for investigation of novel therapeutics in early-stage clinical trials.

Original languageEnglish (US)
Pages (from-to)309-322
Number of pages14
JournalSurgical Oncology Clinics of North America
Issue number2
StatePublished - Apr 1 2015
Externally publishedYes


  • In-transit melanoma
  • Isolated limb infusion
  • Isolated limb perfusion
  • Regional therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology


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