Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Antonia Katsouda, Sofia Iris Bibli, Anastasia Pyriochou, Csaba Szabo, Andreas Papapetropoulos

    Research output: Contribution to journalReview article

    30 Citations (Scopus)

    Abstract

    Recent studies have implicated endogenously produced H2S in the angiogenic process. On one hand, pharmacological inhibition and silencing of the enzymes involved in H2S synthesis attenuate the angiogenic properties of endothelial cells, including proliferation, migration and tube-like structure network formation. On the other hand, enhanced production of H2S by substrate supplementation or over-expression of H2S-producing enzymes leads to enhanced angiogenic responses in cultured endothelial cells. Importantly, H2S up-regulates expression of the key angiogenic factor vascular endothelial growth factor (VEGF) and contributes to the angiogenic signaling in response to VEGF. The signaling pathways mediating H2S-induced angiogenesis include mitogen-activated protein kinases, phosphoinositide-3 kinase, nitric oxide/cGMP-regulated cascades and ATP-sensitive potassium channels. Endogenously produced H2S has also been shown to facilitate neovascularization in prototypical model systems in vivo, and to contribute to wound healing, post-ischemic angiogenesis in the heart and other tissues, as well as in tumor angiogenesis. Targeting of H2S synthesizing enzymes might offer novel therapeutic opportunities for angiogenesis-related diseases.

    Original languageEnglish (US)
    Pages (from-to)175-185
    Number of pages11
    JournalPharmacological Research
    Volume113
    DOIs
    StatePublished - Nov 1 2016

    Fingerprint

    Hydrogen Sulfide
    Vascular Endothelial Growth Factor A
    Enzymes
    Endothelial Cells
    MAP Kinase Kinase 3
    KATP Channels
    1-Phosphatidylinositol 4-Kinase
    Angiogenesis Inducing Agents
    Wound Healing
    Cultured Cells
    Nitric Oxide
    Up-Regulation
    Cell Proliferation
    Pharmacology
    Neoplasms
    Therapeutics

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Regulation and role of endogenously produced hydrogen sulfide in angiogenesis. / Katsouda, Antonia; Bibli, Sofia Iris; Pyriochou, Anastasia; Szabo, Csaba; Papapetropoulos, Andreas.

    In: Pharmacological Research, Vol. 113, 01.11.2016, p. 175-185.

    Research output: Contribution to journalReview article

    Katsouda, Antonia ; Bibli, Sofia Iris ; Pyriochou, Anastasia ; Szabo, Csaba ; Papapetropoulos, Andreas. / Regulation and role of endogenously produced hydrogen sulfide in angiogenesis. In: Pharmacological Research. 2016 ; Vol. 113. pp. 175-185.
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    AU - Pyriochou, Anastasia

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