Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

K. S. Houschyar; C. Tapking; D. Duscher; K. Harati; C. Wallner; J. M. Wagner; Z. N. Maan; S. Rein; M. P. Chelliah; G. Reumuth; G. Grieb; F. Siemers; M. Lehnhardt; B. Behr

doi:10.1055/a-0642-1830

Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

Translated title of the contribution: Regulation of bone metabolism by the Wnt signaling pathway

K. S. Houschyar, C. Tapking, D. Duscher, K. Harati, C. Wallner, J. M. Wagner, Z. N. Maan, S. Rein, M. P. Chelliah, G. Reumuth, G. Grieb, F. Siemers, M. Lehnhardt, B. Behr

Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

Translated title of the contribution	Regulation of bone metabolism by the Wnt signaling pathway
Original language	German
Pages (from-to)	309-318
Number of pages	10
Journal	Handchirurgie Mikrochirurgie Plastische Chirurgie
Volume	51
Issue number	4
DOIs	https://doi.org/10.1055/a-0642-1830
State	Published - 2019

Keywords

Wnt
bone
regeneration
stem cells
ß-catenin

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.1055/a-0642-1830

Cite this

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title = "Regulation des Knochenstoffwechsels durch den Wnt-Signalweg",

abstract = "The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.",

keywords = "Wnt, bone, regeneration, stem cells, {\ss}-catenin",

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doi = "10.1055/a-0642-1830",

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AU - Houschyar, K. S.

AU - Tapking, C.

AU - Duscher, D.

AU - Harati, K.

AU - Wallner, C.

AU - Wagner, J. M.

AU - Maan, Z. N.

AU - Rein, S.

AU - Chelliah, M. P.

AU - Reumuth, G.

AU - Grieb, G.

AU - Siemers, F.

AU - Lehnhardt, M.

AU - Behr, B.

PY - 2019

Y1 - 2019

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AB - The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

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KW - bone

KW - regeneration

KW - stem cells

KW - ß-catenin

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Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

Abstract

Keywords

ASJC Scopus subject areas

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