Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

Translated title of the contribution: Regulation of bone metabolism by the Wnt signaling pathway

K. S. Houschyar, Christian Tapking, D. Duscher, K. Harati, C. Wallner, J. M. Wagner, Z. N. Maan, S. Rein, M. P. Chelliah, G. Reumuth, G. Grieb, F. Siemers, M. Lehnhardt, B. Behr

Research output: Contribution to journalArticle

Abstract

The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

Original languageGerman
Pages (from-to)309-318
Number of pages10
JournalHandchirurgie Mikrochirurgie Plastische Chirurgie
Volume51
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Wnt Signaling Pathway
Wnt Proteins
Bone and Bones
Bone Development
Mesenchymal Stromal Cells
Regeneration
Homeostasis
Cell Death
Stem Cells
Ligands
Therapeutics

Keywords

  • bone
  • regeneration
  • ß-catenin
  • stem cells
  • Wnt

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Houschyar, K. S., Tapking, C., Duscher, D., Harati, K., Wallner, C., Wagner, J. M., ... Behr, B. (2019). Regulation des Knochenstoffwechsels durch den Wnt-Signalweg. Handchirurgie Mikrochirurgie Plastische Chirurgie, 51(4), 309-318. https://doi.org/10.1055/a-0642-1830

Regulation des Knochenstoffwechsels durch den Wnt-Signalweg. / Houschyar, K. S.; Tapking, Christian; Duscher, D.; Harati, K.; Wallner, C.; Wagner, J. M.; Maan, Z. N.; Rein, S.; Chelliah, M. P.; Reumuth, G.; Grieb, G.; Siemers, F.; Lehnhardt, M.; Behr, B.

In: Handchirurgie Mikrochirurgie Plastische Chirurgie, Vol. 51, No. 4, 01.01.2019, p. 309-318.

Research output: Contribution to journalArticle

Houschyar, KS, Tapking, C, Duscher, D, Harati, K, Wallner, C, Wagner, JM, Maan, ZN, Rein, S, Chelliah, MP, Reumuth, G, Grieb, G, Siemers, F, Lehnhardt, M & Behr, B 2019, 'Regulation des Knochenstoffwechsels durch den Wnt-Signalweg', Handchirurgie Mikrochirurgie Plastische Chirurgie, vol. 51, no. 4, pp. 309-318. https://doi.org/10.1055/a-0642-1830
Houschyar KS, Tapking C, Duscher D, Harati K, Wallner C, Wagner JM et al. Regulation des Knochenstoffwechsels durch den Wnt-Signalweg. Handchirurgie Mikrochirurgie Plastische Chirurgie. 2019 Jan 1;51(4):309-318. https://doi.org/10.1055/a-0642-1830
Houschyar, K. S. ; Tapking, Christian ; Duscher, D. ; Harati, K. ; Wallner, C. ; Wagner, J. M. ; Maan, Z. N. ; Rein, S. ; Chelliah, M. P. ; Reumuth, G. ; Grieb, G. ; Siemers, F. ; Lehnhardt, M. ; Behr, B. / Regulation des Knochenstoffwechsels durch den Wnt-Signalweg. In: Handchirurgie Mikrochirurgie Plastische Chirurgie. 2019 ; Vol. 51, No. 4. pp. 309-318.
@article{3dbdf9bd455c474689e62e54f6defe24,
title = "Regulation des Knochenstoffwechsels durch den Wnt-Signalweg",
abstract = "The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.",
keywords = "bone, regeneration, {\ss}-catenin, stem cells, Wnt",
author = "Houschyar, {K. S.} and Christian Tapking and D. Duscher and K. Harati and C. Wallner and Wagner, {J. M.} and Maan, {Z. N.} and S. Rein and Chelliah, {M. P.} and G. Reumuth and G. Grieb and F. Siemers and M. Lehnhardt and B. Behr",
year = "2019",
month = "1",
day = "1",
doi = "10.1055/a-0642-1830",
language = "German",
volume = "51",
pages = "309--318",
journal = "Handchirurgie Mikrochirurgie Plastische Chirurgie",
issn = "0722-1819",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

AU - Houschyar, K. S.

AU - Tapking, Christian

AU - Duscher, D.

AU - Harati, K.

AU - Wallner, C.

AU - Wagner, J. M.

AU - Maan, Z. N.

AU - Rein, S.

AU - Chelliah, M. P.

AU - Reumuth, G.

AU - Grieb, G.

AU - Siemers, F.

AU - Lehnhardt, M.

AU - Behr, B.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

AB - The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

KW - bone

KW - regeneration

KW - ß-catenin

KW - stem cells

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=85070954824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070954824&partnerID=8YFLogxK

U2 - 10.1055/a-0642-1830

DO - 10.1055/a-0642-1830

M3 - Article

VL - 51

SP - 309

EP - 318

JO - Handchirurgie Mikrochirurgie Plastische Chirurgie

JF - Handchirurgie Mikrochirurgie Plastische Chirurgie

SN - 0722-1819

IS - 4

ER -