Regulation des Knochenstoffwechsels durch den Wnt-Signalweg

Translated title of the contribution: Regulation of bone metabolism by the Wnt signaling pathway

K. S. Houschyar, Christian Tapking, D. Duscher, K. Harati, C. Wallner, J. M. Wagner, Z. N. Maan, S. Rein, M. P. Chelliah, G. Reumuth, G. Grieb, F. Siemers, M. Lehnhardt, B. Behr

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

Original languageGerman
Pages (from-to)309-318
Number of pages10
JournalHandchirurgie Mikrochirurgie Plastische Chirurgie
Volume51
Issue number4
DOIs
StatePublished - Jan 1 2019

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Keywords

  • bone
  • regeneration
  • ß-catenin
  • stem cells
  • Wnt

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Houschyar, K. S., Tapking, C., Duscher, D., Harati, K., Wallner, C., Wagner, J. M., Maan, Z. N., Rein, S., Chelliah, M. P., Reumuth, G., Grieb, G., Siemers, F., Lehnhardt, M., & Behr, B. (2019). Regulation des Knochenstoffwechsels durch den Wnt-Signalweg. Handchirurgie Mikrochirurgie Plastische Chirurgie, 51(4), 309-318. https://doi.org/10.1055/a-0642-1830