Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system

György Haskó, Csaba Szabo

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

The sympathetic nervous system innervates immune organs and, when activated, releases its signaling molecules in the vicinity of immune cells. The released molecules include the 'classical' transmitters norepinephrine and epinephrine and the co-transmitters ATP and adenosine. Immune cells express various adrenergic and purinergic receptors that are sensitive to these molecules, and the production of immune/inflammatory mediators (cytokines, chemokines, and free radicals) is modulated by activation of these receptors. Notably, the production of tumor necrosis factor-α, interleukin-6, -10, and -12, and the chemokine macrophage inflammatory protein 1α and the production of the free radical nitric oxide, produced by the inducible nitric oxide synthase, have been shown to be altered by activation of these receptors. Alterations in the production of the immune mediators may contribute to the development of various diseases. On the other hand, novel experimental therapies based on the modulation of adrenergic or purinergic receptors on immune cells are emerging. Such approaches may have beneficial effects in limiting tissue injury and suppressing symptoms in certain pathophysiological states. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)1079-1087
Number of pages9
JournalBiochemical Pharmacology
Volume56
Issue number9
DOIs
StatePublished - Nov 1 1998
Externally publishedYes

Fingerprint

Autonomic Nervous System
Neurology
Chemokines
Purinergic Receptors
Transmitters
Cytokines
Adrenergic Receptors
Free Radicals
Molecules
Macrophage Inflammatory Proteins
Investigational Therapies
Chemical activation
Sympathetic Nervous System
Nitric Oxide Synthase Type II
Interleukin-10
Adenosine
Epinephrine
Interleukin-6
Norepinephrine
Nitric Oxide

Keywords

  • ATP
  • Epinephrine
  • Interleukin
  • Neurotransmission
  • Norepinephrine
  • Purinergic
  • Sympathetic nervous system
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Pharmacology

Cite this

Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system. / Haskó, György; Szabo, Csaba.

In: Biochemical Pharmacology, Vol. 56, No. 9, 01.11.1998, p. 1079-1087.

Research output: Contribution to journalArticle

@article{1cbfcc1816614b5185dcb6c13639a494,
title = "Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system",
abstract = "The sympathetic nervous system innervates immune organs and, when activated, releases its signaling molecules in the vicinity of immune cells. The released molecules include the 'classical' transmitters norepinephrine and epinephrine and the co-transmitters ATP and adenosine. Immune cells express various adrenergic and purinergic receptors that are sensitive to these molecules, and the production of immune/inflammatory mediators (cytokines, chemokines, and free radicals) is modulated by activation of these receptors. Notably, the production of tumor necrosis factor-α, interleukin-6, -10, and -12, and the chemokine macrophage inflammatory protein 1α and the production of the free radical nitric oxide, produced by the inducible nitric oxide synthase, have been shown to be altered by activation of these receptors. Alterations in the production of the immune mediators may contribute to the development of various diseases. On the other hand, novel experimental therapies based on the modulation of adrenergic or purinergic receptors on immune cells are emerging. Such approaches may have beneficial effects in limiting tissue injury and suppressing symptoms in certain pathophysiological states. Copyright (C) 1998 Elsevier Science Inc.",
keywords = "ATP, Epinephrine, Interleukin, Neurotransmission, Norepinephrine, Purinergic, Sympathetic nervous system, Tumor necrosis factor",
author = "Gy{\"o}rgy Hask{\'o} and Csaba Szabo",
year = "1998",
month = "11",
day = "1",
doi = "10.1016/S0006-2952(98)00153-1",
language = "English (US)",
volume = "56",
pages = "1079--1087",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system

AU - Haskó, György

AU - Szabo, Csaba

PY - 1998/11/1

Y1 - 1998/11/1

N2 - The sympathetic nervous system innervates immune organs and, when activated, releases its signaling molecules in the vicinity of immune cells. The released molecules include the 'classical' transmitters norepinephrine and epinephrine and the co-transmitters ATP and adenosine. Immune cells express various adrenergic and purinergic receptors that are sensitive to these molecules, and the production of immune/inflammatory mediators (cytokines, chemokines, and free radicals) is modulated by activation of these receptors. Notably, the production of tumor necrosis factor-α, interleukin-6, -10, and -12, and the chemokine macrophage inflammatory protein 1α and the production of the free radical nitric oxide, produced by the inducible nitric oxide synthase, have been shown to be altered by activation of these receptors. Alterations in the production of the immune mediators may contribute to the development of various diseases. On the other hand, novel experimental therapies based on the modulation of adrenergic or purinergic receptors on immune cells are emerging. Such approaches may have beneficial effects in limiting tissue injury and suppressing symptoms in certain pathophysiological states. Copyright (C) 1998 Elsevier Science Inc.

AB - The sympathetic nervous system innervates immune organs and, when activated, releases its signaling molecules in the vicinity of immune cells. The released molecules include the 'classical' transmitters norepinephrine and epinephrine and the co-transmitters ATP and adenosine. Immune cells express various adrenergic and purinergic receptors that are sensitive to these molecules, and the production of immune/inflammatory mediators (cytokines, chemokines, and free radicals) is modulated by activation of these receptors. Notably, the production of tumor necrosis factor-α, interleukin-6, -10, and -12, and the chemokine macrophage inflammatory protein 1α and the production of the free radical nitric oxide, produced by the inducible nitric oxide synthase, have been shown to be altered by activation of these receptors. Alterations in the production of the immune mediators may contribute to the development of various diseases. On the other hand, novel experimental therapies based on the modulation of adrenergic or purinergic receptors on immune cells are emerging. Such approaches may have beneficial effects in limiting tissue injury and suppressing symptoms in certain pathophysiological states. Copyright (C) 1998 Elsevier Science Inc.

KW - ATP

KW - Epinephrine

KW - Interleukin

KW - Neurotransmission

KW - Norepinephrine

KW - Purinergic

KW - Sympathetic nervous system

KW - Tumor necrosis factor

UR - http://www.scopus.com/inward/record.url?scp=0031741566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031741566&partnerID=8YFLogxK

U2 - 10.1016/S0006-2952(98)00153-1

DO - 10.1016/S0006-2952(98)00153-1

M3 - Article

C2 - 9802316

AN - SCOPUS:0031741566

VL - 56

SP - 1079

EP - 1087

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 9

ER -