Regulation of gastric acid secretion by secretin and serotonin

Laszio Mate, Tsuguo Sakamoto, George H. Greeley, James C. Thompson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a greater magnitude than either secretagogue alone. The administration of methysergide diminished basal concentrations of secretin and abolished the inhibitory effect of secretin on gastric acid secretion. Methysergide also enhanced the stimulatory activity of pentagastrin-induced gastric acid secretion. The inhibitory action of intraduodenal acidification of pentagastrin-induced gastric acid secretion was reversed by methysergide.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalThe American Journal of Surgery
Volume149
Issue number1
DOIs
StatePublished - 1985

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Secretin
Gastric Acid
Serotonin
Methysergide
Pentagastrin
Serotonin Antagonists
Intravenous Administration
Stomach
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Regulation of gastric acid secretion by secretin and serotonin. / Mate, Laszio; Sakamoto, Tsuguo; Greeley, George H.; Thompson, James C.

In: The American Journal of Surgery, Vol. 149, No. 1, 1985, p. 40-45.

Research output: Contribution to journalArticle

Mate, Laszio ; Sakamoto, Tsuguo ; Greeley, George H. ; Thompson, James C. / Regulation of gastric acid secretion by secretin and serotonin. In: The American Journal of Surgery. 1985 ; Vol. 149, No. 1. pp. 40-45.
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