Regulation of Human Drug Metabolism by Dietary Factors

A. H. Conney, M. K. Buening, E. J. Pantuck, C. B. Pantuck, J. G. Fortner, Karl Anderson, A. Kappas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Several dietary factors influence the oxidative metabolism of chemicals in humans. Increasing the ratio of protein to carbohydrate or fat in the diet, feeding cabbage and brussels sprouts or feeding charcoal-broiled beef for several days stimulates human drug metabolism. The chronic ingestion of ethanol stimulates drug metabolism whereas the chronic ingestion of methylxanthine-containing foods inhibits drug metabolism. In contrast, an increase in the ratio of fat to carbohydrate in the diet of normal subjects or the fasting of obese individuals for several days has little or no effect on drug metabolism. Flavonoids in edible plants influence the metabolism of foreign chemicals by human liver in vitro. The addition of flavone, tangeretin or nobiletin to human liver microsomes activates both the hydroxylation of benzo[a]pyrene and the metabolism of aflatoxin B1 to mutagens. On the other hand, quercetin, kaempferol, morin and chrysin, which are also normally occurring flavonoids, inhibit the hydroxylation of benzo[a]pyrene by human liver microsomes.

Original languageEnglish (US)
Title of host publicationEnvironmental Chemicals, Enzyme Function and Human Disease
PublisherJohn Wiley and Sons Ltd.
Pages147-162
Number of pages16
ISBN (Print)9780470720592, 0444901574, 9780444901576
DOIs
StatePublished - May 30 2008
Externally publishedYes

Keywords

  • Chemicals
  • Chronic ingestion
  • Human drug metabolism
  • Human liver mocrosomes
  • Hydroxylation

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Conney, A. H., Buening, M. K., Pantuck, E. J., Pantuck, C. B., Fortner, J. G., Anderson, K., & Kappas, A. (2008). Regulation of Human Drug Metabolism by Dietary Factors. In Environmental Chemicals, Enzyme Function and Human Disease (pp. 147-162). John Wiley and Sons Ltd.. https://doi.org/10.1002/9780470720592.ch9