Regulation of kinesin and cytoplasmic dynein-driven organelle motility

Michael Sheetz, Hanry Yu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We propose that the regulation of kinesin- and cytoplasmic dynein-driven organelle motility is coupled since membrane traffic within cells is largely cyclic and both motors are required to complete the cycles whether the traffic is endocytic, ER-Golgi traffic or granule movements. Coordinated regulation of both motors implies that there may be a central control point. A membrane protein such as kinectin or an accessory factor(s) involved in both kinesin- and cytoplasmic dynein-driven organelle movements constitute the natural focus for regulation of both motors and putative linkages to other cellular processes.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume7
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • Coupled transport
  • Microtubule-based
  • Organelle motor complex

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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